A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics

J Anjum, S Mitra, R Das, R Alam, A Mojumder… - Pharmacological …, 2022 - Elsevier
Abnormalities in the mitogen-activated protein kinase (MAPK) signaling pathway are a key
contributor to the carcinogenesis process and have therefore been implicated in several …

Advances in the biosynthesis and metabolic engineering of rare ginsenosides

M Li, M Ma, Z Wu, X Liang, Q Zheng, D Li, T An… - Applied Microbiology …, 2023 - Springer
Rare ginsenosides are the deglycosylated secondary metabolic derivatives of major
ginsenosides, and they are more readily absorbed into the bloodstream and function as …

Baicalin alleviates oxidative stress and inflammation in diabetic nephropathy via Nrf2 and MAPK signaling pathway

L Ma, F Wu, Q Shao, G Chen, L Xu… - Drug design, development …, 2021 - Taylor & Francis
Background Oxidative stress and inflammation play essential roles in the development and
progression of diabetic nephropathy (DN). Baicalin (BAI), a natural flavonoid, has been …

PM2. 5‐induced pulmonary inflammation via activating of the NLRP3/caspase‐1 signaling pathway

H Jia, Y Liu, D Guo, W He, L Zhao… - Environmental …, 2021 - Wiley Online Library
Abstract Particulate matter 2.5 (PM2. 5)‐induced pulmonary inflammation has become a
public concern in recent years. In which, the activation of the NLRP3/caspase‐1 pathway …

Ingredients with anti-inflammatory effect from medicine food homology plants

Q Lu, R Li, Y Yang, Y Zhang, Q Zhao, J Li - Food chemistry, 2022 - Elsevier
Inflammation occurs when the immune system responses to external harmful stimuli and
infection. Chronic inflammation induces various diseases. A variety of foods are prescribed …

Role of the inflammasome in insulin resistance and type 2 diabetes mellitus

S Lu, Y Li, Z Qian, T Zhao, Z Feng, X Weng… - Frontiers in …, 2023 - frontiersin.org
The inflammasome is a protein complex composed of a variety of proteins in cells and which
participates in the innate immune response of the body. It can be activated by upstream …

Pyroptosis in diabetic nephropathy

A Al Mamun, AA Mimi, Y Wu, M Zaeem, MA Aziz… - Clinica Chimica …, 2021 - Elsevier
Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of
diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro …

Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma

L Qu, Y Liu, J Deng, X Ma, D Fan - Journal of Pharmaceutical Analysis, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Ginsenoside Rk3, an important and rare saponin in heat-treated ginseng, is generated from …

Oxidative stress and ginsenosides: An update on the molecular mechanisms

B He, D Chen, X Zhang, R Yang, Y Yang… - Oxidative medicine …, 2022 - Wiley Online Library
Ginsenosides are a class of active components extracted from ginseng plants (such as
Panax ginseng, Panax quinquefolium, and Panax notoginseng). Ginsenosides have …

Ginsenosides from Panax ginseng as Key Modulators of NF-κB Signaling Are Powerful Anti-Inflammatory and Anticancer Agents

WY Jang, JY Hwang, JY Cho - International Journal of Molecular …, 2023 - mdpi.com
Nuclear factor kappa B (NF-κB) signaling pathways progress inflammation and immune cell
differentiation in the host immune response; however, the uncontrollable stimulation of NF …