Adaptive laboratory evolution is a frequent method in biological studies to gain insights into
the basic mechanisms of molecular evolution and adaptive changes that accumulate in …

Folding and processing of proteins in the endoplasmic reticulum (ER) are major
impediments in the production and secretion of proteins from Pichia pastoris (Komagataella …

Candida glabrata is an opportunistic human fungal pathogen that causes superficial
mucosal and life-threatening bloodstream infections in individuals with a compromised …

Candida glabrata is a successful human opportunistic pathogen which causes superficial
but also life-threatening systemic infections. During infection, C. glabrata has to cope with …

Calcineurin signaling plays diverse roles in fungi in regulating stress responses,
morphogenesis and pathogenesis. Although calcineurin signaling is conserved among …

Regulated Ire1-dependent decay (RIDD) is a feedback mechanism in which the
endoribonuclease Ire1 cleaves endoplasmic reticulum (ER)-localized mRNAs encoding …

Protein kinases play central roles in virtually all signaling pathways that enable organisms to
adapt to their environment. Microbial pathogens must cope with severely restricted iron …

Sensing, responding, and adapting to the surrounding environment are crucial for all living
organisms to survive, proliferate, and differentiate in their biological niches. This ability is …

The unfolded protein response (UPR), crucial for the maintenance of endoplasmic reticulum
(ER) homeostasis, is tied to the regulation of multiple cellular processes in pathogenic fungi …

The unfolded protein response (UPR) remediates endoplasmic reticulum (ER) stress. IRE1,
a component of the UPR, senses misfolded protein and cleaves XBP1 mRNA, which is …