Connecting clinical, environmental, and genetic factors point to an essential role for vitamin A signaling in the pathogenesis of congenital diaphragmatic hernia

RM Gilbert, JP Gleghorn - American Journal of Physiology …, 2023 - journals.physiology.org
Congenital diaphragmatic hernia (CDH) is a developmental disorder that results in
incomplete diaphragm formation, pulmonary hypoplasia, and pulmonary hypertension …

Prenatal management of congenital diaphragmatic hernia

E Danzer, NE Rintoul, KP van Meurs… - Seminars in Fetal and …, 2022 - Elsevier
Recently, two randomized controlled, prospective trials, the Tracheal Occlusion to
Accelerate Lung Growth (TOTAL) trials, reported the outcomes on fetal endoluminal tracheal …

Neonatal and fetal therapy of congenital diaphragmatic hernia-related pulmonary hypertension

FR De Bie, CM Avitabile, L Joyeux, HL Hedrick… - Archives of Disease in …, 2022 - fn.bmj.com
Congenital diaphragmatic hernia (CDH) is a complex malformation characterised by a triad
of pulmonary hypoplasia, pulmonary hypertension (PH) and cardiac ventricular dysfunction …

Pulmonary hypertension in congenital diaphragmatic hernia: Antenatal prediction and impact on neonatal mortality

D Basurto, FM Russo, I Papastefanou… - Prenatal …, 2022 - Wiley Online Library
Objective To determine the prevalence of pulmonary hypertension (PAH) in left‐sided
congenital diaphragmatic hernia (CDH); how we could predict it; and how PAH contributed …

[HTML][HTML] Fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia: a narrative review of the history, current practice, and future directions

EE Perrone, JA Deprest - Translational pediatrics, 2021 - ncbi.nlm.nih.gov
Fetal intervention for fetuses with congenital diaphragmatic hernia (CDH) has been
investigated for over 30 years and is summarized in this manuscript. The review begins with …

Prenatal treprostinil reduces the pulmonary hypertension phenotype in the rat model of congenital diaphragmatic hernia

FR De Bie, CG Halline, T Kotzur, K Hayes, CC Rouse… - …, 2022 - thelancet.com
Background Persistent pulmonary hypertension (PH) causes significant mortality and
morbidity in infants with congenital diaphragmatic hernia (CDH). Since pulmonary vascular …

Atypical fetal brain development in fetuses with non-syndromic isolated musculoskeletal birth defects (niMSBDs)

E Ahmad, O Brumfield, O Masse… - Cerebral …, 2023 - academic.oup.com
Non-syndromic, isolated musculoskeletal birth defects (niMSBDs) are among the leading
causes of pediatric hospitalization. However, little is known about brain development in …

Antenatal sildenafil treatment improves neonatal pulmonary hemodynamics and gas exchange in lambs with diaphragmatic hernia

AJ Kashyap, PLJ Dekoninck… - … in Obstetrics & …, 2019 - Wiley Online Library
Objectives Infants with congenital diaphragmatic hernia (CDH) are predisposed to
pulmonary hypertension after birth, owing to lung hypoplasia that impairs fetal pulmonary …

Congenital Diaphragmatic Hernia: Pulmonary Hypertension and Pulmonary Vascular Disease

SS Moore, RL Keller, G Altit - Clinics in Perinatology, 2024 - perinatology.theclinics.com
Congenital diaphragmatic hernia (CDH) is characterized by a diaphragmatic defect,
associated with abdominal contents herniating into the thorax, with bilateral …

Fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia: systematic review and meta‐analysis

Y Chen, R Xu, X Xie, T Wang, Z Yang… - Ultrasound in Obstetrics …, 2023 - Wiley Online Library
Objective It is debated whether fetal endoscopic tracheal occlusion (FETO) is beneficial to
fetuses with congenital diaphragmatic hernia (CDH) and whether FETO has different effects …