Therapeutic targeting of TEAD transcription factors in cancer
The Hippo signaling pathway inhibits the activity of the oncogenic YAP (Yes-associated
protein)/TAZ (transcriptional co-activator with PDZ-binding motif)–TEAD (TEA/ATTS domain) …
protein)/TAZ (transcriptional co-activator with PDZ-binding motif)–TEAD (TEA/ATTS domain) …
TEAD family transcription factors in development and disease
L Currey, S Thor, M Piper - Development, 2021 - journals.biologists.com
The balance between stem cell potency and lineage specification entails the integration of
both extrinsic and intrinsic cues, which ultimately influence gene expression through the …
both extrinsic and intrinsic cues, which ultimately influence gene expression through the …
[PDF][PDF] Probiotic Lactobacillus rhamnosus GG Prevents Liver Fibrosis Through Inhibiting Hepatic Bile Acid Synthesis and Enhancing Bile Acid Excretion in Mice
Y Liu, K Chen, F Li, Z Gu, Q Liu, L He, T Shao… - …, 2020 - Wiley Online Library
Background and Aims Cholestatic liver disease is characterized by gut dysbiosis and
excessive toxic hepatic bile acids (BAs). Modification of gut microbiota and repression of BA …
excessive toxic hepatic bile acids (BAs). Modification of gut microbiota and repression of BA …
TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: An implication in early human pregnancy loss
Early pregnancy loss affects∼ 15% of all implantation-confirmed human conceptions.
However, evolutionarily conserved molecular mechanisms that regulate self-renewal of …
However, evolutionarily conserved molecular mechanisms that regulate self-renewal of …
Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells
Adipocyte differentiation is driven by waves of transcriptional regulators that reprogram the
enhancer landscape and change the wiring of the promoter interactome. Here, we use high …
enhancer landscape and change the wiring of the promoter interactome. Here, we use high …
3D adipose tissue culture links the organotypic microenvironment to improved adipogenesis
Obesity and type 2 diabetes are strongly associated with adipose tissue dysfunction and
impaired adipogenesis. Understanding the molecular underpinnings that control …
impaired adipogenesis. Understanding the molecular underpinnings that control …
Glucocorticoid receptor signaling activates TEAD4 to promote breast cancer progression
L He, L Yuan, Y Sun, P Wang, H Zhang, X Feng… - Cancer research, 2019 - AACR
The Hippo pathway plays a critical role in cell growth and tumorigenesis. The activity of TEA
domain transcription factor 4 (TEAD4) determines the output of Hippo signaling; however …
domain transcription factor 4 (TEAD4) determines the output of Hippo signaling; however …
[HTML][HTML] Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading
The mechanoregulated proteins YAP/TAZ are involved in the adipogenic/osteogenic switch
of mesenchymal stem cells (MSCs). MSC fate decision can be unbalanced by controlling …
of mesenchymal stem cells (MSCs). MSC fate decision can be unbalanced by controlling …
TEAD4 as an Oncogene and a Mitochondrial Modulator
SC Hsu, CY Lin, YY Lin, CC Collins… - Frontiers in Cell and …, 2022 - frontiersin.org
TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein
of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in …
of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in …
VGLL4 promotes vascular endothelium specification via TEAD1 in the vascular organoids and human pluripotent stem cells-derived endothelium model
Y Quan, M Hu, J Jiang, P Jin, J Fan, M Li, X Fan… - Cellular and Molecular …, 2023 - Springer
Background We have shown that Hippo-YAP signaling pathway plays an important role in
endothelial cell differentiation. Vestigial-like family member 4 (VGLL4) has been identified …
endothelial cell differentiation. Vestigial-like family member 4 (VGLL4) has been identified …