The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

Genetic interactions identify combinations of genetic variants that impinge on phenotype.
With whole-genome sequence information available for thousands of individuals within a …

Seminal yeast studies have established the value of comprehensively mapping genetic
interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets …

INTRODUCTION Genetic interactions are identified when variants in different genes
combine to generate an unusual phenotype compared with the expected combined effect of …

INTRODUCTION Tumor genome sequencing has revealed that, beyond a few commonly
mutated genes, most mutations that affect cancer genomes are rare. To interpret these rare …

Biological systems are by nature multiscale, consisting of subsystems that factor into
progressively smaller units in a deeply hierarchical structure. At any level of the hierarchy …

Turnover of the 26S proteasome by autophagy is an evolutionarily conserved process that
governs cellular proteolytic capacity and eliminates inactive particles. In most organisms …

Macroautophagy is an intracellular degradation system that involves the de novo formation
of membrane structures called autophagosomes, although the detailed process by which …

Cargo-selective and nonselective autophagy pathways employ a common core autophagy
machinery that directs biogenesis of an autophagosome that eventually fuses with the …

The LRRK2 gene is a major contributor to genetic risk for Parkinson's disease and
understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of …