Integration of GC–MS and LC–MS for untargeted metabolomics profiling
Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …
scientific community as it is applied in several researches relating to diseases diagnosis …
[HTML][HTML] Discovery and resupply of pharmacologically active plant-derived natural products: A review
AG Atanasov, B Waltenberger… - Biotechnology …, 2015 - Elsevier
Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …
therapeutic potential, and nowadays still represent an important pool for the identification of …
Metabolite identification and quantitation in LC-MS/MS-based metabolomics
Metabolomics aims at detection and quantitation of all metabolites in biological samples.
The presence of metabolites with a wide variety of physicochemical properties and different …
The presence of metabolites with a wide variety of physicochemical properties and different …
Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy
WB Dunn, DI Broadhurst, HJ Atherton… - Chemical society …, 2011 - pubs.rsc.org
The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …
Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database
Untargeted metabolomics provides a comprehensive platform for identifying metabolites
whose levels are altered between two or more populations. By using liquid chromatography …
whose levels are altered between two or more populations. By using liquid chromatography …
HILIC‐MS for metabolomics: An attractive and complementary approach to RPLC‐MS
Hydrophilic interaction chromatography (HILIC) is an emerging separation mode of liquid
chromatography (LC). Using highly hydrophilic stationary phases capable of retaining …
chromatography (LC). Using highly hydrophilic stationary phases capable of retaining …
Dereplication: racing to speed up the natural products discovery process
SP Gaudêncio, F Pereira - Natural product reports, 2015 - pubs.rsc.org
Covering: 1993–2014 (July) To alleviate the dereplication holdup, which is a major
bottleneck in natural products discovery, scientists have been conducting their research …
bottleneck in natural products discovery, scientists have been conducting their research …
Toward global metabolomics analysis with hydrophilic interaction liquid chromatography–mass spectrometry: improved metabolite identification by retention time …
Metabolomics is an emerging field of postgenomic biology concerned with comprehensive
analysis of small molecules in biological systems. However, difficulties associated with the …
analysis of small molecules in biological systems. However, difficulties associated with the …
Coupling liquid chromatography to Orbitrap mass spectrometry
A Makarov, M Scigelova - Journal of Chromatography A, 2010 - Elsevier
The Orbitrap mass analyzer has become a mainstream mass spectrometry technique. In
addition to providing a brief introduction to the Orbitrap technology and its continuing …
addition to providing a brief introduction to the Orbitrap technology and its continuing …
Hydrophilic interaction chromatography coupled to MS for metabonomic/metabolomic studies
Hydrophilic interaction chromatography (HILIC) is a relatively recently introduced mode of
liquid‐phase separations. Recently, HILIC has been used for coupling to MS in …
liquid‐phase separations. Recently, HILIC has been used for coupling to MS in …