The stealth effect plays a central role on capacitating nanomaterials for drug delivery
applications through improving the pharmacokinetics such as blood circulation …

Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

Ionizable lipid nanoparticles (LNPs) have been widely used for in vivo delivery of RNA
therapeutics into the liver. However, a main challenge remains to develop LNP formulations …

Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Human organoids, self-organized and differentiated from homogenous pluripotent stem cells
(PSC), replicate the key structural and functional characteristics of their in vivo counterparts …

Lipid nanoparticles (LNPs) are the leading nonviral technologies for the delivery of
exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies …

The accumulation of senescent cells can drive many age-associated phenotypes and
pathologies. Consequently, it has been proposed that removing senescent cells might …

Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …

Nanomaterials (NMs) are widely used in commercial and medical products, such as
cosmetics, vaccines, and drug carriers. Exposure to NMs via various routes such as dermal …

Non-alcoholic fatty liver disease (NAFLD) and its complications are an expanding health
problem associated with the metabolic syndrome. Liver sinusoidal endothelial cells (LSECs) …