Glomerular Filtration and Albuminuria Chronic kidney diseases generally arise from a
disordered kidney filtration barrier within glomeruli. This review describes the roles of …

The glomerular basement membrane (GBM) is a key component of the glomerular capillary
wall and is essential for kidney filtration. The major components of the GBM include …

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

Recent molecular insights have established the podocyte as a key component of the
glomerular filtration barrier, and hence an important common pathway in proteinuric …

Diabetic nephropathy (DN) is among the most lethal complications that occur in type 1 and
type 2 diabetics. Podocyte dysfunction is postulated to be a critical event associated with …

Familial idiopathic nephrotic syndromes represent a heterogeneous group of kidney
disorders, and include autosomal recessive steroid-resistant nephrotic syndrome, which is …

Focal and segmental glomerulosclerosis 1 (FSGS) is a common, non-specific renal lesion.
Although it is often secondary to other disorders, including HIV infection, obesity …

The visceral glomerular epithelial cell, also called podocyte, is a terminally differentiated cell
that lines the outer aspect of the glomerular basement membrane (GBM). It therefore forms …

Transforming growth factor-β1 (TGF-β1) is established to be involved in the pathogenesis of
diabetic nephropathy. The diabetic milieu enhances oxidative stress and induces the …