The cytosine analogues 5‐azacytosine (azacytidine) and 2′‐deoxy‐5‐azacytidine
(decitabine) are the currently most advanced drugs for epigenetic cancer therapies. These …

One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …

The human equilibrative nucleoside transporter 1 (hENT1), a member of the SLC29 family,
plays crucial roles in adenosine signaling, cellular uptake of nucleoside for DNA and RNA …

Increasingly, the effectiveness of adjuvant chemotherapy agents for breast cancer has been
related to changes in the genomic profile of tumors. We investigated correspondence …

Concentrative nucleoside transporters (CNT; SLC28) and equilibrative nucleoside
transporters (ENT; SLC29) mediate the uptake of natural nucleosides and a variety of …

Nucleoside and nucleobase analogs are currently used in the treatment of solid tumors,
lymphoproliferative diseases, viral infections such as hepatitis and AIDS, and some …

Mantle cell lymphoma (MCL) is a B-cell malignancy characterized by a poor response to
treatment and prognosis. Constitutive activation of different signaling pathways in subsets of …

Simple Summary Despite access to a vast arsenal of anticancer agents, many fail to realise
their full therapeutic potential in clinical practice. One key determinant of this is the evolution …

Non-Hodgkin lymphomas (NHL) are lymphoid tumors that arise by a complex process of
malignant transformation of mature lymphocytes during various stages of differentiation. The …

Despite the sequencing of the human genome, the rate of innovative and successful drug
discovery in the pharmaceutical industry has continued to decrease. Leaving aside …