Entry of bacteria into host cells is an important virulence mechanism. Through peptidoglycan
recognition, the nucleotide-binding oligomerization domain (NOD) proteins NOD1 and …

Recently, substantial advances in the understanding of the molecular pathogenesis of
inflammatory bowel disease (IBD) have been made owing to three related lines of …

A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty
in older persons, but the molecular mechanisms of such decline are not understood. Here …

It has been long recognized that NOD1 and NOD2 are critical players in the host immune
response, primarily by their sensing bacterial peptidoglycan‐conserved motifs. Significant …

Nucleotide oligomerization domain (NOD)‐like receptors (NLRs) are a specialized group of
intracellular proteins that play a critical role in the regulation of the host innate immune …

The NOD-like receptors (NLRs) are a specialized group of intracellular receptors that
represent a key component of the host innate immune system. Since the discovery of the first …

The intracellular Nod-like proteins or receptors are a family of sensors of intracellularly
encountered microbial motifs and'danger signals' that have emerged as being critical …

Significant advances in our understanding of innate immunity have been made following the
identification of three families of pathogen sensors: Toll-like receptors (TLRs), NOD-like …

BACKGROUND & AIMS: The identification of numerous genes that confer susceptibility to
Crohn's disease (CD) indicates that this complex disease might arise from alterations in …

Sensing intracellular pathogens is a process mediated by innate immune cells that is crucial
for the induction of inflammatory processes and effective adaptive immune responses …