Under normal circumstances, the coagulation system is balanced in favour of
anticoagulation.• Thrombin is the key effector enzyme of the clotting cascade.• Antagonists of …

Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to
activated Protein C and an increased risk for venous thromboembolism. Deep venous …

Identifying genomic regions that have been targets of natural selection remains one of the
most important and challenging areas of research in genetics. To this end, we report an …

Background Obstetrical complications such as severe preeclampsia, abruptio placentae,
fetal growth retardation, and stillbirth are associated with intervillous or spiral-artery …

Pulmonary thromboembolism is the main cause of maternal death in the UK and current
trends show an increase. Deep-vein thrombosis underlies this disorder. Important issues …

Perioperative bleeding is a major challenge particularly because of increasing clinical use of
potent antithrombotic drugs. Understanding current concepts of coagulation is important in …

Venous thrombosis, whose main clinical presentations include deep vein thrombosis and
pulmonary embolism, represents a major health problem worldwide. Numerous conditions …

Pregnancy is hypercoagulable state. The field of thrombophilia; the tendency to thrombosis,
has been developed rapidly and has been linked to many aspects of pregnancy. It is …

OBJECTIVE: This systematic review examines the strength of the association between
thrombophilia and recurrent pregnancy loss and other serious obstetric complications …

Platelet‐mediated primary haemostasis and blood coagulation have evolved as important
defence mechanisms against bleeding. The formation of the platelet plug provides the initial …