Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

Much evidence shows that physical exercise (PE) is a strong gene modulator that induces
structural and functional changes in the brain, determining enormous benefit on both …

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

Cytokines are pleiotropic molecules with important roles in inflammatory responses. Pro-
inflammatory cytokines and neuroinflammation are important not only in inflammatory …

Human and animal studies suggest an intriguing link between mitochondrial diseases and
depression. Although depression has historically been linked to alterations in …

Recent studies have suggested that mitochondrial dysfunction and dysregulated
neuroinflammatory pathways are involved in the pathophysiology of major depressive …

Background Completed suicide is a major cause of death in bipolar disorder (BD) patients.
Objective The aim of this paper is to provide an overall review of the existing literature of …

Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …

Major psychiatric illnesses such as mood disorders and schizophrenia are chronic, recurrent
mental illnesses that affect the lives of millions of individuals. Although these disorders have …

This review provides an overview of the current methods for quantifying mitochondrial
ultrastructure, including cristae morphology, mitochondrial contact sites, and recycling …