Developing phage therapy that overcomes the evolution of bacterial resistance

A Oromí-Bosch, JD Antani… - Annual Review of Virology, 2023 - annualreviews.org
The global rise of antibiotic resistance in bacterial pathogens and the waning efficacy of
antibiotics urge consideration of alternative antimicrobial strategies. Phage therapy is a …

Bacteriophage and bacterial susceptibility, resistance, and tolerance to antibiotics

Q Chen, T Dharmaraj, PC Cai, EB Burgener… - Pharmaceutics, 2022 - mdpi.com
Bacteriophages, viruses that infect and replicate within bacteria, impact bacterial responses
to antibiotics in complex ways. Recent studies using lytic bacteriophages to treat bacterial …

Multistep diversification in spatiotemporal bacterial-phage coevolution

E Shaer Tamar, R Kishony - Nature Communications, 2022 - nature.com
The evolutionary arms race between phages and bacteria, where bacteria evolve resistance
to phages and phages retaliate with resistance-countering mutations, is a major driving force …

Retrospective, observational analysis of the first one hundred consecutive cases of personalized bacteriophage therapy of difficult-to-treat infections facilitated by a …

JP Pirnay, S Djebara, G Steurs, J Griselain, C Cochez… - MedRxiv, 2023 - medrxiv.org
In contrast to the many reports of successful cases of personalized bacteriophage therapy,
randomized controlled trials of non-personalized bacteriophage products did not bring the …

Evolutionary dynamics between phages and bacteria as a possible approach for designing effective phage therapies against antibiotic-resistant bacteria

M Hasan, J Ahn - Antibiotics, 2022 - mdpi.com
With the increasing global threat of antibiotic resistance, there is an urgent need to develop
new effective therapies to tackle antibiotic-resistant bacterial infections. Bacteriophage …

Phage therapy for pulmonary infections: lessons from clinical experiences and key considerations

G Mitropoulou, A Koutsokera, C Csajka… - European …, 2022 - Eur Respiratory Soc
Lower respiratory tract infections lead to significant morbidity and mortality. They are
increasingly caused by multidrug-resistant pathogens, notably in individuals with cystic …

Personalized bacteriophage therapy outcomes for 100 consecutive cases: a multicentre, multinational, retrospective observational study

JP Pirnay, S Djebara, G Steurs, J Griselain… - Nature …, 2024 - nature.com
In contrast to the many reports of successful real-world cases of personalized bacteriophage
therapy (BT), randomized controlled trials of non-personalized bacteriophage products have …

Characterization of phage resistance and their impacts on bacterial fitness in Pseudomonas aeruginosa

N Li, Y Zeng, M Wang, R Bao, Y Chen, X Li… - Microbiology …, 2022 - Am Soc Microbiol
The emergence and spread of antibiotic resistance pose serious environmental and health
challenges. Attention has been drawn to phage therapy as an alternative approach to …

Case report: Analysis of phage therapy failure in a patient with a Pseudomonas aeruginosa prosthetic vascular graft infection

L Blasco, I López-Hernández… - Frontiers in …, 2023 - frontiersin.org
Clinical case of a patient with a Pseudomonas aeruginosa multidrug-resistant prosthetic
vascular graft infection which was treated with a cocktail of phages (PT07, 14/01, and PNM) …

Targeting Pseudomonas aeruginosa biofilm with an evolutionary trained bacteriophage cocktail exploiting phage resistance trade-offs

F Kunisch, C Campobasso, J Wagemans… - Nature …, 2024 - nature.com
Spread of multidrug-resistant Pseudomonas aeruginosa strains threatens to render currently
available antibiotics obsolete, with limited prospects for the development of new antibiotics …