Carvacrol (CV) is a phenolic monoterpenoid found in essential oils of oregano (Origanum
vulgare), thyme (Thymus vulgaris), pepperwort (Lepidium flavum), wild bergamot (Citrus …

Carvacrol is a monoterpenic phenol produced by an abundant number of aromatic plants,
including thyme and oregano. Presently, carvacrol is used in low concentrations as a food …

Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily are responsible for the
metabolism of many drugs, environmental chemicals and endogenous compounds …

In order to minimize expensive drug failures, is essential to determine potential activity,
toxicity and ADME problems as early as possible. In view of the large libraries of compounds …

Cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT), which both exist as
enzyme “superfamilies,” are together responsible for the metabolism of most hepatically …

Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily contribute to the
elimination of drugs from almost all therapeutic classes. Awareness of the importance of …

Monoterpenes, volatile metabolites produced by plants, are involved in the taste and aroma
perception of fruits and vegetables and have been used for centuries in gastronomy, as food …

Although computational tools have been used to predict toxic responses resulting from
molecules binding either as substrates or inhibitors to proteins, there are complications to be …

Drug discovery and development is generally done in the commercial rather than the
academic realm. Drug discovery involves target discovery and validation, lead identification …

Partial least squares discriminant analysis (PLSDA), Bayesian regularized artificial neural
network (BRANN), and support vector machine (SVM) methodologies were compared by …