IL-6/JAK/STAT3 signaling in breast cancer metastasis: biology and treatment

SG Manore, DL Doheny, GL Wong, HW Lo - Frontiers in oncology, 2022 - frontiersin.org
Breast cancer is the most commonly diagnosed cancer in women. Metastasis is the primary
cause of mortality for breast cancer patients. Multiple mechanisms underlie breast cancer …

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

DE Johnson, RA O'Keefe, JR Grandis - Nature reviews Clinical …, 2018 - nature.com
Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …

The role of IL-6 in cancer cell invasiveness and metastasis—overview and therapeutic opportunities

M Rašková, L Lacina, Z Kejík, A Venhauerová… - Cells, 2022 - mdpi.com
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various
homeostatic and pathological processes. These activities range from regulating embryonic …

IL-6 as a keystone cytokine in health and disease

CA Hunter, SA Jones - Nature immunology, 2015 - nature.com
Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …

Interleukin-6 signaling pathway and its role in kidney disease: an update

H Su, CT Lei, C Zhang - Frontiers in immunology, 2017 - frontiersin.org
Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and
inflammatory response but also affects hematopoiesis, metabolism, and organ development …

[HTML][HTML] Obesity-induced TNFα and IL-6 signaling: the missing link between obesity and inflammation—driven liver and colorectal cancers

L Kern, MJ Mittenbühler, AJ Vesting, AL Ostermann… - Cancers, 2019 - mdpi.com
Cancers | Free Full-Text | Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between
Obesity and Inflammation—Driven Liver and Colorectal Cancers Next Article in Journal Effects …

Interleukin-6 and its receptors: a highly regulated and dynamic system

J Wolf, S Rose-John, C Garbers - Cytokine, 2014 - Elsevier
Abstract Interleukin-6 (IL-6) is a multifunctional cytokine with well-defined pro-and anti-
inflammatory properties. Although only small amounts in the picogram range can be …

[HTML][HTML] IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6

S Rose-John - International journal of biological sciences, 2012 - ncbi.nlm.nih.gov
Abstract Interleukin-6 (IL-6) is a cytokine with many activities. It has functions in the
regulation of the immune system and the nervous system. Furthermore, IL-6 is involved in …

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

SA Jones, J Scheller… - The Journal of clinical …, 2011 - Am Soc Clin Investig
The successful treatment of certain autoimmune conditions with the humanized anti–IL-6
receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines …

Role of cytokines in rheumatoid arthritis

M Feldmann, FM Brennan… - Annual review of …, 1996 - annualreviews.org
▪ Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such …