Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and
placenta) are stably colonized by microbial communities in a healthy pregnancy remains a …

The rapid development of next-generation sequencing (NGS) technology, including
advances in sequencing chemistry, sequencing technologies, bioinformatics, and data …

Tumor-resident intracellular microbiota is an emerging tumor component that has been
documented for a variety of cancer types with unclear biological functions. Here, we …

Microorganisms are detected in multiple cancer types, including in putatively sterile organs,
but the contexts in which they influence oncogenesis or anti-tumor responses in humans …

The human fetal immune system begins to develop early during gestation; however, factors
responsible for fetal immune-priming remain elusive. We explored potential exposure to …

Background Microbiome studies often involve sequencing a marker gene to identify the
microorganisms in samples of interest. Sequence classification is a critical component of this …

We sought to determine whether pre-eclampsia, spontaneous preterm birth or the delivery of
infants who are small for gestational age were associated with the presence of bacterial …

The innate immune system is the oldest protection strategy that is conserved across all
organisms. Although having an unspecific action, it is the first and fastest defense …

Metagenomic next-generation sequencing (mNGS) is increasingly being applied in clinical
laboratories for unbiased culture-independent diagnosis. Whether it can be a next routine …

It is often taken for granted that all animals host and depend upon a microbiome, yet this has
only been shown for a small proportion of species. We propose that animals span a …