[HTML][HTML] Overview of hepatitis B virus mutations and their implications in the management of infection
P Caligiuri, R Cerruti, G Icardi… - World journal of …, 2016 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) affects approximately two billion people worldwide and more than
240 million people in the world are currently chronic carrier that could develop serious …
240 million people in the world are currently chronic carrier that could develop serious …
[HTML][HTML] Clinical implications of hepatitis B virus mutations: recent advances
I Lazarevic - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) infection is a major cause of acute and chronic hepatitis, and of its
long-term complications. It is the most variable among DNA viruses, mostly because of its …
long-term complications. It is the most variable among DNA viruses, mostly because of its …
Global occurrence of clinically relevant hepatitis b virus variants as found by analysis of publicly available sequencing data
Several viral factors impact the natural course of hepatitis B virus (HBV) infection, the
sensitivity of diagnostic tests, or treatment response to interferon-α and nucleos (t) ide …
sensitivity of diagnostic tests, or treatment response to interferon-α and nucleos (t) ide …
A computational chemistry perspective on the current status and future direction of hepatitis B antiviral drug discovery
D Morgnanesi, EJ Heinrichs, AR Mele, S Wilkinson… - Antiviral research, 2015 - Elsevier
Computational chemical biology, applied to research on hepatitis B virus (HBV), has two
major branches: bioinformatics (statistical models) and first-principle methods (molecular …
major branches: bioinformatics (statistical models) and first-principle methods (molecular …
Increased occurrence of mutant rtI233V of HBV in patients receiving adefovir therapy
Y Liu, S Xin, X Ye, R Chen, Z Xu, X Li, H Ye… - Antiviral …, 2016 - journals.sagepub.com
Background The study aimed to clarify whether the rtI233V substitution affects adefovir
(ADV) resistance. Methods A total of 18,419 patients from Beijing 302 Hospital were …
(ADV) resistance. Methods A total of 18,419 patients from Beijing 302 Hospital were …
Virtual screening in hepatitis B virus drug discovery: current stateof-the-art and future perspectives
M Elmessaoudi-Idrissi, A Blondel… - Current Medicinal …, 2018 - ingentaconnect.com
Hepatitis B Virus (HBV) is a major global health burden. Interferon alpha and nucleos (t) ide
analogues are currently the standard-of-care for chronic HBV infection. However, these …
analogues are currently the standard-of-care for chronic HBV infection. However, these …
Coevolution analysis of amino-acids reveals diversified drug-resistance solutions in viral sequences: a case study of hepatitis B virus
The study of mutational landscapes of viral proteins is fundamental for the understanding of
the mechanisms of cross-resistance to drugs and the design of effective therapeutic …
the mechanisms of cross-resistance to drugs and the design of effective therapeutic …
乙型肝炎病毒阿德福韦酯耐药相关变异的研究进展
叶晓玲， 刘妍， 徐东平 - 实用肝脏病杂志, 2016 - manu43.magtech.com.cn
目前口服核苷酸类似物阿德福韦酯(adefovir dipivoxil, ADV) 仍是我国临床治疗慢性乙型肝炎(
chronic hepatitis B, CHB) 的主要抗病毒药物之一. 但是, 长期服用ADV 可能导致乙型肝炎病毒 …
chronic hepatitis B, CHB) 的主要抗病毒药物之一. 但是, 长期服用ADV 可能导致乙型肝炎病毒 …
Analysis of evolution and virological characteristics of rtI233V mutations in the hepatitis B virus reverse transcriptase domain
YE Xiao-ling, LIU Yan, C Rong-juan… - Jie Fang Jun Yi Xue …, 2015 - search.proquest.com
Objective To analyze the evolution of rtI233V mutation in the reverse transcriptase domain of
hepatitis B virus (HBV) and its association with adefovir dipivoxil (ADV) resistance. Methods …
hepatitis B virus (HBV) and its association with adefovir dipivoxil (ADV) resistance. Methods …
[HTML][HTML] HBV 基因组常见突变及临床意义
胡爱荣， 胡婷 - 临床肝胆病杂志, 2016 - lcgdbzz.com
HBV 基因组特殊的结构及生活周期特点决定了其易于突变. 突变改变了病毒的生物学行为和
对抗病毒药物的敏感性, 影响治疗效果和疾病的进展. 前S/S 开放读码框(ORF) 以点突变为主 …
对抗病毒药物的敏感性, 影响治疗效果和疾病的进展. 前S/S 开放读码框(ORF) 以点突变为主 …