Unraveling the therapeutic effects of mesenchymal stem cells in asthma

F Mirershadi, M Ahmadi, A Rezabakhsh… - Stem Cell Research & …, 2020 - Springer
Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness,
chronic inflammatory response, and excessive structural remodeling. The current …

Effect of mesenchymal stromal (stem) cell (MSC) transplantation in asthmatic animal models: a systematic review and meta-analysis

LB Zhang, M He - Pulmonary pharmacology & therapeutics, 2019 - Elsevier
Background Over the years, mesenchymal stromal (stem) cells (MSCs) have been pre-
clinically applied in the treatment of variety kinds of diseases including asthma and chronic …

Systemic delivery of mesenchymal stem cells condition media in repeated doses acts as magic bullets in restoring IFN-γ/IL-4 balance in asthmatic rats

R Keyhanmanesh, R Rahbarghazi, MR Aslani… - Life sciences, 2018 - Elsevier
Aims With respect to recent advantage in stem cell application, given the concern reported
previously after stem cell transplantation, mesenchymal stem cell-derived conditioned media …

Bone marrow mesenchymal stem cells and their conditioned media could potentially ameliorate ovalbumin-induced asthmatic changes

M Ahmadi, R Rahbarghazi, MR Aslani… - Biomedicine & …, 2017 - Elsevier
Background The major feature of asthma is governed by chronic airway inflammation. This
investigation was proposed to achieve the suitable candidate for ameliorating long-term …

Bone marrow mesenchymal stem cells and condition media diminish inflammatory adhesion molecules of pulmonary endothelial cells in an ovalbumin-induced …

R Rahbarghazi, R Keyhanmanesh, MR Aslani… - Microvascular …, 2019 - Elsevier
Objectives Although excitements related to stem cell therapeutic outcomes have been
highlighted enormously in asthma, the vast majority of works were conducted by researchers …

Human adipose tissue-derived mesenchymal stem cells attenuate atopic dermatitis by regulating the expression of MIP-2, miR-122a-SOCS1 axis, and Th1/Th2 …

M Kim, SH Lee, Y Kim, Y Kwon, Y Park… - Frontiers in …, 2018 - frontiersin.org
The objective of this study was to investigate the effect of human adipose tissue-derived
mesenchymal stem cells (AdMSCs) on atopic dermatitis (AD) in the BALB/c mouse model …

Effect of high fat diet on NF‐кB microRNA146a negative feedback loop in ovalbumin‐sensitized rats

G Akhavanakbari, B Babapour, MR Alipour… - Biofactors, 2019 - Wiley Online Library
The present study aimed to investigate the role of microRNA‐146a and its adapter proteins
[interleukin‐1 receptor‐associated kinase 1 (IRAK1) and tumor necrosis factor (TNF) …

Systemic transplantation of mesenchymal stem cells modulates endothelial cell adhesion molecules induced by ovalbumin in rat model of asthma

R Keyhanmanesh, R Rahbarghazi, M Ahmadi - Inflammation, 2018 - Springer
Achieving the optimal clinical outcome of mesenchymal stem cells (MSCs) is particularly
dependent on fundamental understanding of therapeutic mechanisms. The current study …

[HTML][HTML] Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression levels in lung tissue of ovalbumin-sensitized mice

MR Aslani, Z Jafari, R Rahbarghazi… - Iranian journal of …, 2022 - ncbi.nlm.nih.gov
Objective (s): Although various studies have revealed the beneficial effects of crocin (derived
from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator …

Monitoring IL-13 expression in relation to miRNA-155 and miRNA-133 changes following intra-tracheal administration of mesenchymal stem cells and conditioned …

M Ahmadi, R Rahbarghazi… - The Thai Journal of …, 2018 - digital.car.chula.ac.th
The overall goal of the current study was to show possibly mechanisms by which
mesenchymal stem cells (MSCs) or conditioned media (CM) exert immune-modulatory …