Liver macrophages in health and disease
M Guilliams, CL Scott - Immunity, 2022 - cell.com
Single-cell and spatial transcriptomic technologies have revealed an underappreciated
heterogeneity of liver macrophages. This has led us to rethink the involvement of …
heterogeneity of liver macrophages. This has led us to rethink the involvement of …
Lipolysis: cellular mechanisms for lipid mobilization from fat stores
The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …
acids from fat stores in adipose tissue to generate energy has experienced major revisions …
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
SCC Huang, B Everts, Y Ivanova, D O'sullivan… - Nature …, 2014 - nature.com
Alternative (M2) activation of macrophages driven via the α-chain of the receptor for
interleukin 4 (IL-4Rα) is important for immunity to parasites, wound healing, the prevention of …
interleukin 4 (IL-4Rα) is important for immunity to parasites, wound healing, the prevention of …
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis
Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque.
However, plaque progression renders macrophages unable to degrade exogenous …
However, plaque progression renders macrophages unable to degrade exogenous …
Linking disease associations with regulatory information in the human genome
Genome-wide association studies have been successful in identifying single nucleotide
polymorphisms (SNPs) associated with a large number of phenotypes. However, an …
polymorphisms (SNPs) associated with a large number of phenotypes. However, an …
Genetics of human cardiovascular disease
S Kathiresan, D Srivastava - Cell, 2012 - cell.com
Cardiovascular disease encompasses a range of conditions extending from myocardial
infarction to congenital heart disease, most of which are heritable. Enormous effort has been …
infarction to congenital heart disease, most of which are heritable. Enormous effort has been …
[HTML][HTML] Lysosomal acid lipase deficiency–an under-recognized cause of dyslipidaemia and liver dysfunction
Lysosomal acid lipase deficiency (LAL-D) is a rare autosomal recessive lysosomal storage
disease caused by deleterious mutations in the LIPA gene. The age at onset and rate of …
disease caused by deleterious mutations in the LIPA gene. The age at onset and rate of …
Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets
BACKGROUND Endometriosis is a heritable common gynaecological condition influenced
by multiple genetic and environmental factors. Genome-wide association studies (GWASs) …
by multiple genetic and environmental factors. Genome-wide association studies (GWASs) …