Retinal degeneration and Alzheimer's disease: an evolving link

A Ashok, N Singh, S Chaudhary… - International journal of …, 2020 - mdpi.com
Age-related macular degeneration (AMD) and glaucoma are degenerative conditions of the
retina and a significant cause of irreversible blindness in developed countries. Alzheimer's …

Digital cognitive biomarker for mild cognitive impairments and dementia: a systematic review

Z Ding, TL Lee, AS Chan - Journal of clinical medicine, 2022 - mdpi.com
The dementia population is increasing as the world's population is growing older. The
current systematic review aims to identify digital cognitive biomarkers from computerized …

Estimating the sensorimotor components of cybersickness

S Weech, JP Varghese… - Journal of …, 2018 - journals.physiology.org
The user base of the virtual reality (VR) medium is growing, and many of these users will
experience cybersickness. Accounting for the vast interindividual variability in cybersickness …

The TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer's disease and estimate 5-year risks of …

J Alty, Q Bai, R Li, K Lawler, RJ St George, E Hill… - BMC neurology, 2022 - Springer
Background The worldwide prevalence of dementia is rapidly rising. Alzheimer's disease
(AD), accounts for 70% of cases and has a 10–20-year preclinical period, when brain …

Regional brain atrophy and cognitive decline depend on definition of subjective cognitive decline

C Morrison, M Dadar, N Shafiee, S Villeneuve… - NeuroImage: Clinical, 2022 - Elsevier
Background People with subjective cognitive decline (SCD) may be at increased risk for
Alzheimer's disease (AD). However, not all studies have observed this increased risk. This …

Differentiation of patients with mild cognitive impairment and healthy controls based on computer assisted hand movement analysis: a proof-of-concept study

AA Horvath, DB Berente, B Vertes, D Farkas… - Scientific Reports, 2022 - nature.com
Mild cognitive impairment (MCI) is the prodromal phase of dementia, and it is highly
underdiagnosed in the community. We aimed to develop an automated, rapid (< 5 min) …

Hand motor dysfunction is associated with both subjective and objective cognitive impairment across the dementia continuum

KD Rudd, K Lawler, ML Callisaya, J Alty - Dementia and Geriatric …, 2024 - karger.com
Introduction: Motor dysfunction is an important feature of early-stage dementia. Gait provides
a non-invasive biomarker across the dementia continuum. Gait speed and rhythm aid risk …

Adults at increased Alzheimer's disease risk display cognitive-motor integration impairment associated with changes in resting-state functional connectivity: a …

KM Hawkins, LE Sergio - Journal of Alzheimer's Disease, 2016 - content.iospress.com
Background: Many neuroimaging parameters have demonstrated utility as biomarkers in
preclinical AD, including resting-state functional connectivity in the default mode network …

Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers

SH Stout, GM Babulal, C Ma, DB Carr, DM Head… - Alzheimer's & …, 2018 - Elsevier
Introduction With 36 million older adult US drivers, safety is a critical concern, particularly
among those with dementia. It is unclear at what stage of Alzheimer's disease (AD) older …

Development of a smartphone screening test for preclinical Alzheimer's disease and validation across the dementia continuum

J Alty, LR Goldberg, E Roccati, K Lawler, Q Bai… - BMC neurology, 2024 - Springer
Background Dementia prevalence is predicted to triple to 152 million globally by 2050.
Alzheimer's disease (AD) constitutes 70% of cases. There is an urgent need to identify …