Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

The process of pyroptosis is mediated by inflammasomes and a downstream effector known
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …

The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

Vaccinations are one of the most important preventive tools against infectious diseases.
Over time, many different types of vaccines have been developed concerning the antigen …

Innate immunity is the first response to protect against pathogens and cellular insults.
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …

Caspases are a family of conserved cysteine proteases that play key roles in programmed
cell death and inflammation. In multicellular organisms, caspases are activated via …

The precise mechanism by which oral infection contributes to the pathogenesis of extra-oral
diseases remains unclear. Here, we report that periodontal inflammation exacerbates gut …

The gastrointestinal tract harbors numerous commensal bacteria, referred to as the
microbiota, that benefit host health by digesting dietary components and eliminating …