Globally, the number of new HIV infections remains unacceptably high, and urgent new
approaches are needed to advance HIV vaccine science. However, the development of a …

The development of subunit vaccine platforms has been of considerable interest due to their
good safety profile and ability to be adapted to new antigens, compared to other vaccine …

Hepatitis C virus (HCV) infection affects approximately 58 million people and causes~
300,000 deaths yearly. The only target for HCV neutralizing antibodies is the highly …

Defending against future pandemics requires vaccine platforms that protect across a range
of related pathogens. Nanoscale patterning can be used to address this issue. Here, we …

Prime-boost regimens for COVID-19 vaccines elicit poor antibody responses against
Omicron-based variants and employ frequent boosters to maintain antibody levels. We …

Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize
antigens and enhance humoral immunity through multivalent antigen display. However, P …

One of the strategies towards an effective HIV-1 vaccine is to elicit broadly neutralizing
antibody responses that target the high HIV-1 Env diversity. Here, we present an HIV-1 …

The development of an effective and durable vaccine remains a central goal in the fight
against malaria. Circumsporozoite protein (CSP) is the major surface protein of sporozoites …

Vaccination has saved billions of human lives and has considerably reduced the economic
burden associated with pandemic and endemic infectious diseases. Notwithstanding major …

Self-assembling protein nanoparticles are beneficial platforms for enhancing the often weak
and short-lived immune responses elicited by subunit vaccines. Their benefits include …