The purpose of this review is to summarize the research progress of PI3K/Akt signaling
pathway in erythropoiesis and glycolysis. Phosphatidylinositol‑4, 5‑bisphosphate 3‑kinase …

Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

Sepsis causes over 200,000 deaths yearly in the US; better treatments are urgently needed.
Administering bone marrow stromal cells (BMSCs—also known as mesenchymal stem cells) …

The diverse physiological actions of the “biologic gases,” O2, CO, NO, and H2S, have
attracted much interest. Initially viewed as toxic substances, CO, NO, and H2S play important …

Tissue hypoxia in solid tumors is caused by several pathological changes associated with
tumor growth, including altered microvasculature structure, increased diffusional distances …

Human SARS‐CoV‐2 infection is characterized by a high mortality rate due to some patients
developing a large innate immune response associated with a cytokine storm and acute …

Hypoxia-inducible factor (HIF) is a transcriptional activator that coordinates adaptive
responses to hypoxia. An increased activity is recognized in the majority of clinical relevant …

The glycemic index (GI) indicates how fast blood glucose is raised after consuming a
carbohydrate-containing food. Human metabolic studies indicate that GI is related to patho …

N-myc down-regulated gene 1 (NDRG1) is a known metastasis suppressor in multiple
cancers, being also involved in embryogenesis and development, cell growth and …

Induction and activation of nitric oxide (NO) synthases (NOS) and excessive production of
NO are common features of almost all diseases associated with infection and acute or …