The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

L Kooshki, SN Zarneshan, S Fakhri, SZ Moradi… - Phytomedicine, 2023 - Elsevier
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

Mechanism of dihydromyricetin on inflammatory diseases

Y Sun, S Liu, S Yang, C Chen, Y Yang, M Lin… - Frontiers in …, 2022 - frontiersin.org
Inflammation plays a crucial role in a variety of diseases, including diabetes, arthritis,
asthma, Alzheimer's disease (AD), acute cerebral stroke, cancer, hypertension, and …

Development of pectin/chitosan-based electrospun biomimetic nanofiber membranes loaded with dihydromyricetin inclusion complexes for wound healing application

H Guo, W Ran, X Jin, Y Huang, F Long, Y Xiao… - International Journal of …, 2024 - Elsevier
Accidents and surgical procedures inevitably lead to wounds, presenting clinical challenges
such as inflammation and microbial infections that impede the wound-healing process. This …

Suppression of Inflammatory Responses by Dihydromyricetin, a Flavonoid from Ampelopsis grossedentata, via Inhibiting the Activation of NF-κB and MAPK Signaling …

XL Hou, Q Tong, WQ Wang, CY Shi… - Journal of natural …, 2015 - ACS Publications
Ampelopsis grossedentata, an indigenous plant in southern China, has been used for
treating pharyngitis in traditional Chinese medicine for hundreds of years. In this study, we …

[HTML][HTML] Molecular mechanisms and therapeutic implications of dihydromyricetin in liver disease

J Chen, X Wang, T Xia, Y Bi, B Liu, J Fu… - Biomedicine & …, 2021 - Elsevier
Recent studies demonstrated that dihydromyricetin (DHM) has prominent therapeutic effects
on liver injury and liver cancer. By summarizing the current preclinical in vitro and in vivo …

Dihydromyricetin-loaded pickering emulsions stabilized by dialdehyde cellulose nanocrystals for preparation of antioxidant gelatin–based edible films

J Xu, X Li, Y Xu, A Wang, Z Xu, X Wu, D Li… - Food and Bioprocess …, 2021 - Springer
Surfactant-free Pickering emulsion has been considered as a promising carrier to load oil-
soluble active agents for preparation of active edible films to keep food quality and safety …

The versatile effects of dihydromyricetin in health

H Li, Q Li, Z Liu, K Yang, Z Chen… - Evidence‐Based …, 2017 - Wiley Online Library
Dihydromyricetin is a flavonoid isolated from Ampelopsis grossedentata, which is
traditionally used in China. Dihydromyricetin exhibits health‐benefiting activities with …

Gastrointestinal stability of dihydromyricetin, myricetin, and myricitrin: an in vitro investigation

D Xiang, C Wang, W Wang, C Shi, W Xiong… - … journal of food …, 2017 - Taylor & Francis
The gastrointestinal (GI) stability of three flavonoids, dihydromyricetin (DMY), myricetin
(MYR), and myricitrin (MYT), was examined in simulated physiological fluids. Several factors …

[HTML][HTML] Recent update on application of dihydromyricetin in metabolic related diseases

Y Wang, J Wang, H Xiang, P Ding, T Wu, G Ji - Biomedicine & …, 2022 - Elsevier
As a new type of natural flavonoids, dihydromyricetin (DMY) has attracted more and more
attention. It has a series of pharmacological effects, such as anti-inflammatory, anti-tumor …

Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

Z Ren, Y Zhao, T Cao, X Zhen - Acta Pharmacologica Sinica, 2016 - nature.com
Aim: It is general believed that mitochondrial dysfunction and oxidative stress play critical
roles in the pathology of Parkinson's disease (PD). Dihydromyricetin (DHM), a natural …