Growing epidemiological evidence indicates an association between obesity, type 2
diabetes, and certain cancers, suggesting the existence of common underlying mechanisms …

The transcription factor NRF2 is known as the master regulator of the oxidative stress
response. Tumor entities presenting oncogenic activation of NRF2, such as lung …

Background Seaweed polysaccharides have been recommended as anticancer
supplements and for boosting human health; however, their benefits in the treatment of triple …

We aim to investigate the roles and mechanisms of NR3C2 in colorectal cancer (CRC). The
expression of NR3C2 in CRC tumours and paired paracancerous tissues of 71 CRC …

Triple‑negative breast cancer (TNBC) cells obtain energy mainly through aerobic glycolysis,
and their glycolytic rate is significantly higher compared with that of non‑TNBC cells …

Objective To explore the role of p300 in the context of paclitaxel (PTX) resistance in triple-
negative breast cancer (TNBC) cells, focusing on its interaction with the …

The existence of molecular links that facilitate colorectal cancer (CRC) development in the
population with type 2 diabetes (T2D) is supported by substantial epidemiological evidence …

Background Colorectal cancers with defects in the Mismatch Repair (MMR) system
represent a minority of the disease. MMR defective cancers are characterized by high Tumor …

In this study, we explore the role of nuclear survivin in maintaining the effector phenotype of
IFNγ-producing T cells acting through the transcriptional control of glucose utilization. High …

Posttranslational modifications of epigenetic modifiers provide a flexible and timely
mechanism for rapid adaptations to the dynamic environment of cancer cells. SIRT1 is an …