The use of psychoactive drugs is a wide spread behaviour in human societies. The
systematic use of a drug requires the establishment of different drug use-associated …

Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …

Of the many conceptual distinctions present in psychology today, the approach-avoidance
distinction stands out as one of, if not the, most fundamental and basic. The distinction …

Suicidality is exceedingly prevalent in pain patients. Although the pathophysiology of this
link remains unclear, it may be potentially related to the partial congruence of physical and …

This article discusses the role of the lateral hypothalamic area (LHA) in feeding and drinking
and draws on data obtained from lesion and stimulation studies and neurochemical and …

Multiple lines of research have implicated the mesolimbic dopamine system in drug reward
measured by either the drug self-administration or conditioned place preference paradigm …

The hypothesis that the dopaminergic system plays a role in feeding behavior was tested in
three experiments. First, microdialysis was performed in the nucleus accumbens (NAC) at 20 …

Serotonin1A-receptors (5-HT1A-Rs) are important components of the 5-HT system in the
brain. As somatodendritic autoreceptors they control the activity of 5-HT neurons, and, as …

Midbrain dopamine neurons fire irregularly, with interspersed clusters of high-frequency
spikes, commonly called 'bursts'. In this review we examine such heterogeneity in activity …

Understanding systems for approach and avoidance is basic for behavioral neuroscience.
Research on the neural organization and functions of the dorsal striatum in movement …