RNA duplex stability depends strongly on ionic conditions, and inside cells RNAs are
exposed to both monovalent and multivalent ions. Despite recent advances, we do not have …

RNA hairpins play a pivotal role in a diverse range of cellular functions, and are integral
components of ribozymes, mRNA, and riboswitches. However, the mechanistic and kinetic …

RNA is a key participant in many biological processes, but studies of RNA using computer
simulations lag behind those of proteins, largely due to less-developed force fields and the …

An important characteristic of RNA folding is the adoption of alternative configurations of
similar stability, often referred to as misfolded configurations. These configurations are …

Time-resolved temperature-jump/drop infrared (IR) spectroscopy has been used to measure
the impact of stem base sequence on the melting and refolding dynamics of ribonucleic acid …

RNA functions are intrinsically tied to folding kinetics. The most elementary step in RNA
folding is the closing and opening of a base pair. Understanding this elementary rate …

Two decades into the genomics era the question of mapping sequence to function has
evolved from identifying functional elements to characterizing their quantitative properties …

Determining the structural dynamics of RNA and DNA is essential to understanding their
cellular function, but direct measurement of strand association or folding remains …

We have investigated the multidimensionality of the free energy landscape accessible to a
nucleic acid hairpin by measuring the relaxation kinetics in response to two very different …

Single-stranded DNA and RNA hairpin structures with 4–10 nucleotides (nt) in the loop and
5–8 basepairs (bp) in the stem fold on 10–100 μs timescale. In contrast, theoretical estimate …