Molecular activatable probes with near‐infrared (NIR) fluorescence play a critical role in in
vivo imaging of biomarkers for drug screening and disease diagnosis. With structural …

Proteins are involved in many biological processes. Misfolded, truncated, or mutated
proteins as well as over-or underexpressed proteins have been implicated in many …

Expansion microscopy (ExM) is a powerful technique to overcome the diffraction limit of light
microscopy that can be applied in both tissues and cells. In ExM, samples are embedded in …

Water-soluble organic fluorophores are widely used as labels in biological systems.
However, in many cases these fluorophores can interact strongly with lipid bilayers …

Single-molecule methods have become widely used for quantifying the conformational
heterogeneity and structural dynamics of biomolecules in vitro. Their application in vivo …

Glucose is a ubiquitous energy source for most living organisms. Its uptake activity closely
reflects cellular metabolic demand in various physiopathological conditions. Extensive …

In situ measurement of cellular metabolites is still a challenge in biology. Conventional
methods, such as mass spectrometry or fluorescence microscopy, would either destroy the …

Amorphous solid dispersion formulations (ASD) are increasingly being used as a
formulation strategy to improve bioavailability of poorly soluble drugs. One of the limitations …

Using the ultraviolet autofluorescence of tryptophan amino acids offers fascinating
perspectives to study single proteins without the drawbacks of fluorescence labeling …

Tumor cell‐surface markers are usually overexpressed or mutated protein receptors for
which spatiotemporal regulation differs between and within cancers. Single‐molecule …