CRISPR/Cas technology has revolutionized the fields of the genome-and epigenome-
editing by supplying unparalleled control over genomic sequences and expression …

Parkinson's disease (PD), a neurodegenerative disorder, is a life-altering, debilitating
disease exhibiting a severe physical, psychological, and financial burden on patients …

Parkinson's disease (PD) is the most common neurological movement disorder
characterized by the selective and irreversible loss of dopaminergic neurons in substantia …

Gene therapy has emerged as a promising therapeutic strategy for various conditions,
including blood disorders, ocular disease, cancer, and nervous system disorders. The …

Dementia with Lewy bodies (DLB) is pathologically defined by the cytoplasmic accumulation
of alpha-synuclein (aSyn) within neurons in the brain. Predominately pre-synaptic, aSyn has …

Various forms of Parkinson's disease, including its common sporadic form, are characterized
by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of …

Nucleocytoplasmic transport (NCT) across the nuclear envelope is precisely regulated in
eukaryotic cells, and it plays critical roles in maintenance of cellular homeostasis …

Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous
inclusions represents the key histophathological hallmark of a spectrum of …

Parkinson's disease (PD) is characterized by Lewy bodies (composed predominantly of
alpha-synuclein [aSyn]) and loss of pigmented midbrain dopaminergic neurons comprising …

Parkinson's disease (PD) and other chronic and debilitating neurodegenerative diseases
(NDs) impose a substantial medical, emotional, and financial burden on individuals and …