This review examines the history of psychiatric nosology, with particular reference to the
nineteenth-century origins of the concepts of manic-depressive illness and schizophrenia as …

Abstracts Prepulse inhibition (PPI) of startle is an operational measure of sensorimotor
gating that is often impaired in patients with schizophrenia. Despite the large number of …

In this study, we investigated whether intrinsic glial dysfunction contributes to the
pathogenesis of schizophrenia (SCZ). Our approach was to establish humanized glial …

Background Startle inhibition by weak prepulses (PPI) is studied to understand the biology
of information processing in schizophrenia patients and healthy comparison subjects (HCS) …

Predictive coding has played a transformative role in the study of psychosis, casting
delusions and hallucinations as statistical inference in a system with abnormal precision …

Background Psychopathological research is moving from a specific approach towards
transdiagnosis through the analysis of processes that appear transversally to multiple …

Psychosis–an impaired contact with reality–is a hallmark of schizophrenia. Many psychotic
symptoms are associated with disruptions in agency–the sense that 'I'cause my actions. A …

Smooth pursuit eye tracking deficits are a promising intermediate phenotype for
schizophrenia and possibly for psychotic disorders more broadly. The Bipolar …

Studies of eye movement have become an essential tool of basic neuroscience research.
Measures of eye movement have been applied to higher brain functions such as cognition …

The mainstream approach to psychopathological phenotypes is focussed on easy-to-assess
operationalizable symptoms. Thinness of phenotypes and simplification of clinical constructs …