Impaired tuning of neural ensembles and the pathophysiology of schizophrenia: a translational and computational neuroscience perspective
The functional optimization of neural ensembles is central to human higher cognitive
functions. When the functions through which neural activity is tuned fail to develop or break …
functions. When the functions through which neural activity is tuned fail to develop or break …
[HTML][HTML] Connectome disconnectivity and cortical gene expression in patients with schizophrenia
Background Genome-wide association studies have identified several common risk loci for
schizophrenia (SCZ). In parallel, neuroimaging studies have shown consistent findings of …
schizophrenia (SCZ). In parallel, neuroimaging studies have shown consistent findings of …
Molecular mechanisms underlying noncoding risk variations in psychiatric genetic studies
Recent large-scale genetic approaches such as genome-wide association studies have
allowed the identification of common genetic variations that contribute to risk architectures of …
allowed the identification of common genetic variations that contribute to risk architectures of …
An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data
CY Zhang, X Xiao, Z Zhang, Z Hu, M Li - Molecular Psychiatry, 2022 - nature.com
Alternative splicing of schizophrenia risk genes, such as DRD2, GRM3, and DISC1, has
been extensively described. Nevertheless, the alternative splicing characteristics of the …
been extensively described. Nevertheless, the alternative splicing characteristics of the …
Decreased CNNM2 expression in prefrontal cortex affects sensorimotor gating function, cognition, dendritic spine morphogenesis and risk of schizophrenia
DY Zhou, X Su, Y Wu, Y Yang, L Zhang… - …, 2024 - nature.com
Genome-wide association studies (GWASs) have reported multiple single nucleotide
polymorphisms (SNPs) associated with schizophrenia, yet the underlying molecular …
polymorphisms (SNPs) associated with schizophrenia, yet the underlying molecular …
A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MTd2d3 and Mushroom Dendritic Spine Density
Recent advances in functional genomics have facilitated the identification of multiple genes
and isoforms associated with the genetic risk of schizophrenia, yet the causal variations …
and isoforms associated with the genetic risk of schizophrenia, yet the causal variations …
The ERG1 K+ Channel and Its Role in Neuronal Health and Disease
FG Sanchez-Conde, EN Jimenez-Vazquez… - Frontiers in Molecular …, 2022 - frontiersin.org
The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac
electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology …
electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology …
The contribution of alternative splicing to genetic risk for psychiatric disorders
E Reble, A Dineen, CL Barr - Genes, Brain and Behavior, 2018 - Wiley Online Library
A genetic contribution to psychiatric disorders has clearly been established and genome‐
wide association studies now provide the location of risk genes and genetic variants …
wide association studies now provide the location of risk genes and genetic variants …
Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo
Abstract Autism Spectrum Disorders (ASD) comprise a range of early age-onset
neurodevelopment disorders with genetic heterogeneity. Most ASD related genes are …
neurodevelopment disorders with genetic heterogeneity. Most ASD related genes are …
Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress
Y Chen, S Li, T Zhang, F Yang, B Lu - Iscience, 2022 - cell.com
While schizophrenia pathogenesis involves both genetic and environmental factors, their
specific combinations remain ill-defined. Here we show that deficiency in promoter VI-driven …
specific combinations remain ill-defined. Here we show that deficiency in promoter VI-driven …