Retina as a potential biomarker in schizophrenia spectrum disorders: a systematic review and meta-analysis of optical coherence tomography and electroretinography

H Komatsu, G Onoguchi, SM Silverstein, S Jerotic… - Molecular …, 2024 - nature.com
Introduction Abnormal findings on optical coherence tomography (OCT) and
electroretinography (ERG) have been reported in participants with schizophrenia spectrum …

Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis

H Komatsu, G Onoguchi, S Jerotic, N Kanahara… - Molecular …, 2022 - nature.com
Introduction The retina shares structural and functional similarities with the brain.
Furthermore, structural changes in the retina have been observed in patients with …

Neuroretinal alterations in schizophrenia and bipolar disorder: an updated meta-analysis

N Sheehan, D Bannai, SM Silverstein… - Schizophrenia …, 2024 - academic.oup.com
Schizophrenia (SZ) and bipolar disorder (BD) are characterized by major symptomatic,
cognitive, and neuroanatomical changes. Recent studies have used optical coherence …

Optical coherence tomography reveals retinal thinning in schizophrenia spectrum disorders

E Boudriot, B Schworm, L Slapakova, K Hanken… - European Archives of …, 2023 - Springer
Abstract Background Schizophrenia spectrum disorders (SSDs) are presumed to be
associated with retinal thinning. However, evidence is lacking as to whether these retinal …

[HTML][HTML] Association between polygenic risk for schizophrenia and retinal morphology: A cross-sectional analysis of the United Kingdom Biobank

BA Blose, SM Silverstein, KV Stuart, PA Keane… - Psychiatry …, 2024 - Elsevier
We examined the relationship between genetic risk for schizophrenia (SZ), using polygenic
risk scores (PRSs), and retinal morphological alterations. Retinal structural and vascular …

[HTML][HTML] Measures of retinal structure and function as biomarkers in neurology and psychiatry

SM Silverstein, DL Demmin, JB Schallek… - Biomarkers in …, 2020 - Elsevier
Investigators have increasingly turned to studying the retina as a window into brain structure
and function. In neuropsychiatric diseases, retinal anatomy as assessed by optical …

The multimodal Munich Clinical Deep Phenotyping study to bridge the translational gap in severe mental illness treatment research

L Krčmář, I Jäger, E Boudriot, K Hanken… - Frontiers in …, 2023 - frontiersin.org
Introduction Treatment of severe mental illness (SMI) symptoms, especially negative
symptoms and cognitive dysfunction in schizophrenia, remains a major unmet need. There …

Quantifying retinal microvascular morphology in schizophrenia using swept-source optical coherence tomography angiography

D Bannai, I Adhan, R Katz, LA Kim… - Schizophrenia …, 2022 - academic.oup.com
Background Retinovascular changes are reported on fundus imaging in schizophrenia (SZ).
This is the first study to use swept-source optical coherence tomography angiography (OCT …

A systematic review and meta-analysis of optical coherence tomography studies in schizophrenia, bipolar disorder and major depressive disorder

A Prasannakumar, V Kumar, P Mailankody… - The World Journal of …, 2023 - Taylor & Francis
Objectives Due to the common neurodevelopmental origin and easy accessibility, the retina
serves as a surrogate marker for changes in the brain. Hence, Optical Coherence …

Structural and functional retinal alterations in patients with paranoid schizophrenia

EBN Friedel, HT Hahn, S Maier, S Küchlin… - Translational …, 2022 - nature.com
Ophthalmological methods have increasingly raised the interest of neuropsychiatric
specialists. While the integrity of the retinal cell functions can be evaluated with the …