Angiogenic signaling pathways and anti-angiogenic therapy for cancer
ZL Liu, HH Chen, LL Zheng, LP Sun… - Signal transduction and …, 2023 - nature.com
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …
Structural insights of oxindole based kinase inhibitors as anticancer agents: Recent advances
P Dhokne, AP Sakla, N Shankaraiah - European journal of medicinal …, 2021 - Elsevier
Small-molecule kinase inhibitors are being continuously explored as new anticancer
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …
Design and synthesis of thiazolidine-2, 4-diones hybrids with 1, 2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: In-vitro anticancer evaluation …
Abstract A thiazolidine-2, 4-dione nucleus was molecularly hybridised with the effective
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
Exploration of novel VEGFR2 tyrosine kinase inhibitors via design and synthesis of new alkylated indolyl-triazole Schiff bases for targeting breast cancer
MS Nafie, ATA Boraei - Bioorganic Chemistry, 2022 - Elsevier
Abstract According to the World Health Organization (WHO) statistics: In 2020, there were
2.3 million women diagnosed with breast cancer and 685,000 deaths globally. Therefore …
2.3 million women diagnosed with breast cancer and 685,000 deaths globally. Therefore …
New quinoxaline-2 (1 H)-ones as potential VEGFR-2 inhibitors: Design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations
Eleven new quinoxaline derivatives were designed and synthesized as modified VEGFR-2
inhibitors of our previous work. The synthesized compounds were tested against three …
inhibitors of our previous work. The synthesized compounds were tested against three …
Discovery of new quinoxaline-2 (1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation
VEGF/VEGFR2 pathway is the crucial therapeutic target in the treatment of cancer. So that, a
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
Design, synthesis, and in vitro and in vivo anti-angiogenesis study of a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor based on 1, 2, 3 …
D Wang, K Liu, X Li, G Lu, W Xue, X Qian… - European Journal of …, 2021 - Elsevier
In the past five years, our team had been committed to click chemistry research, exploring
the biological activity of 1, 2, 3-triazole by synthesizing different target inhibitors. In this study …
the biological activity of 1, 2, 3-triazole by synthesizing different target inhibitors. In this study …
Identification of new [1, 2, 4] triazolo [4, 3-a] quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies
Tumor angiogenesis is mainly regulated by VEGFR-2. In this study, a new series of [1, 2, 4]
triazolo [4, 3-a] quinoxaline based-derivatives has been designed and synthesized to …
triazolo [4, 3-a] quinoxaline based-derivatives has been designed and synthesized to …
Logical synthetic strategies and structure-activity relationship of indolin-2-one hybrids as small molecule anticancer agents: An overview
This review focuses on the potential of indolin-2-one in the treatment of cancer as a
chemotherapeutic nucleus and highlights significant recent progress in the synthetic …
chemotherapeutic nucleus and highlights significant recent progress in the synthetic …
Synthesis of new bioactive indolyl-1, 2, 4-triazole hybrids as dual inhibitors for EGFR/PARP-1 targeting breast and liver cancer cells
Cancer is the most severe disease worldwide. Every year, tens of millions of people are
diagnosed with cancer, and over half of those people will ultimately die from the disease …
diagnosed with cancer, and over half of those people will ultimately die from the disease …