Strategies for the synthesis of Stemona alkaloids: an update

WJ Olivier, JS Henneveld, JA Smith… - Natural product …, 2022 - pubs.rsc.org
Covering: 2009 to 2022 The Stemona alkaloids, which are found in plant species from the
family Stemonaceae, represent a tremendously large and structurally-diverse family of …

Recent developments in transannular reactions

E Reyes, L Prieto, L Carrillo, U Uria, JL Vicario - Synthesis, 2022 - thieme-connect.com
Transannular reactions have shown a remarkable performance for the construction of
polycyclic scaffolds from medium-or large-sized cyclic molecules in an unconventional …

Computer-aided key step generation in alkaloid total synthesis

Y Lin, R Zhang, D Wang, T Cernak - Science, 2023 - science.org
Efficient chemical synthesis is critical to satisfying future demands for medicines, materials,
and agrochemicals. Retrosynthetic analysis of modestly complex molecules has been …

Ir-catalyzed asymmetric total syntheses of bisdehydrotuberostemonine D, putative bisdehydrotuberostemonine E and structural revision of the latter

Y Deng, X Liang, K Wei, YR Yang - Journal of the American …, 2021 - ACS Publications
The first total syntheses of bisdehydrotuberostemonine D (8) and putative
bisdehydrotuberostemonine E (9), two novel pyrrole Stemona alkaloids, along with the …

Asymmetric total syntheses of five pyrrole-type Stemona alkaloids

X Wang, T Shi, G Yin, Y Wang, Z Li… - Organic Chemistry …, 2022 - pubs.rsc.org
The asymmetric total syntheses of five pyrrole-type Stemona alkaloids and two
stereoisomers were accomplished, among which 3-n-butylneostemonine and …

Total syntheses of seven stemoamide-type Stemona alkaloids

T Shi, F Cao, J Chen, X Wang, G Yin… - Organic Chemistry …, 2022 - pubs.rsc.org
Six Stemona alkaloids were synthesized racemically using stemoamide, obtained via a
cascade cyclization or our reported transannular cyclization of parvistemoamide, as the …

Structural Revision of the Stemona Alkaloids Tuberostemonine O, Dehydrocroomines A and B, and Dehydrocroomine

JM Jiang, ZH Shi, XW Yang, D Zhu… - Journal of Natural …, 2022 - ACS Publications
The structural revision of four Stemona alkaloids from Stemona tuberosa is reported. The
misassignment of the tuberostemonine O structure (1) was recognized when a new alkaloid …

Recent advances in the transformations of different types of Stemona alkaloids

T Shi, X Wang, J Chen, F Cao, G Yin… - Organic Chemistry …, 2022 - pubs.rsc.org
In recent years, researches on the total syntheses of Stemona alkaloids with different 5/7
bicyclic systems have attracted increasing attention, and the development momentum in this …

Lactam strategy using amide-selective nucleophilic addition for quick access to complex amines: unified total synthesis of stemoamide-type alkaloids

Y Sugiyama, Y Soda, M Yoritate… - Bulletin of the …, 2022 - academic.oup.com
Our research group has been exploring a lactam strategy for the concise total synthesis of
complex alkaloids. In this article, we report full details of the unified total synthesis of …

Structural Revision of Parvistemoamide: Informing Biosynthetic Proposals of Stemona Alkaloids

WJ Olivier, JA Smith, AC Bissember - Organic Letters, 2022 - ACS Publications
The natural product parvistemoamide was isolated in 1991 and has ostensibly eluded
synthesis. Its distinctive assigned structure represents the first and only Stemona alkaloid …