To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …

Cancer-associated fibroblasts (CAFs) are activated fibroblasts in the tumor
microenvironment. They are one of the most prominent cell types in the stroma and produce …

Oral cancers are among the common head and neck malignancies. Different anticancer
therapy modalities such as chemotherapy, immunotherapy, radiation therapy, and also …

Approximately 15% of cancers are attributable to the inflammatory process, and growing
evidence supports an association between oral squamous cell carcinoma (OSCC) and …

Background Local resident normal fibroblasts (NFs) are the major source of cancer-
associated fibroblasts (CAFs), which are distinguishable from NFs by their tumor-supportive …

The role of the tumour microenvironement (TME) in cancer progression and resistance to
therapies is now widely recognized. The most prominent non-immune cell type in the …

Oral squamous cell carcinoma (OSCC) is among the most commonly diagnosed
malignancies in the world. Patients with OSCC often develop treatment resistance, resulting …

Fisetin (FS) is an anticancer drug having potential role in oral tumors management.
However, its clinical application is limited due to its hydrophobicity and instability. Bioactive …

Complex interactions take place during cancer formation and progression. In this regard,
there has been increasing focus on the non-malignant cells that make up the tumour …