The catalytic mechanisms of binuclear metallohydrolases
Binuclear metallohydrolases are a structurally diverse group of enzymes that use binuclear
metal ion centers to catalyze the hydrolysis of amides and esters of carboxylic and …
metal ion centers to catalyze the hydrolysis of amides and esters of carboxylic and …
Purple acid phosphatase: a journey into the function and mechanism of a colorful enzyme
Purple acid phosphatases (PAPs) catalyze the hydrolysis of a wide range of
phosphomonoester and amide substrates. These enzymes have been identified and …
phosphomonoester and amide substrates. These enzymes have been identified and …
Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle
G Schenk, TW Elliott, E Leung, LE Carrington… - BMC structural …, 2008 - Springer
Background Purple acid phosphatases belong to the family of binuclear metallohydrolases
and are involved in a multitude of biological functions, ranging from bacterial killing and …
and are involved in a multitude of biological functions, ranging from bacterial killing and …
The reaction mechanism of the Ga (III) Zn (II) derivative of uteroferrin and corresponding biomimetics
SJ Smith, A Casellato, KS Hadler, N Mitić… - JBIC Journal of …, 2007 - Springer
Purple acid phosphatase from pig uterine fluid (uteroferrin), a representative of the diverse
family of binuclear metallohydrolases, requires a heterovalent Fe (III) Fe (II) center for …
family of binuclear metallohydrolases, requires a heterovalent Fe (III) Fe (II) center for …
[HTML][HTML] Asymmetric dinuclear metal complexes as models for active sites in hydrolases and redox enzymes
M Jarenmark, H Carlsson, E Nordlander - Comptes Rendus Chimie, 2007 - Elsevier
Recent advances in the synthesis of biomimetic asymmetric dinuclear transition metal
complexes are reviewed. Emphasis is put on description of asymmetric model complexes for …
complexes are reviewed. Emphasis is put on description of asymmetric model complexes for …
Inhibition of purple acid phosphatase with α-alkoxynaphthylmethylphosphonic acids
Purple acid phosphatases (PAPs) are binuclear hydrolases that catalyse the hydrolysis of a
range of phosphorylated substrates. Human PAP is a major histochemical marker for the …
range of phosphorylated substrates. Human PAP is a major histochemical marker for the …
Inhibition studies of purple acid phosphatases: implications for the catalytic mechanism
TW Elliott, N Mitic, LR Gahan, LW Guddat… - Journal of the Brazilian …, 2006 - SciELO Brasil
Purple acid phosphatases (PAPs) belong to the family of binuclear metallohydrolases and
catalyse the hydrolysis of a large group of phosphoester substrates at acidic pH. Despite …
catalyse the hydrolysis of a large group of phosphoester substrates at acidic pH. Despite …
Substrate positioning by His92 is important in catalysis by purple acid phosphatase
EG Funhoff, Y Wang, G Andersson… - The FEBS …, 2005 - Wiley Online Library
Proteolysis of single polypeptide mammalian purple acid phosphatases (PAPs) results in the
loss of an interaction between the loop residue Asp146 and the active site residues Asn91 …
loss of an interaction between the loop residue Asp146 and the active site residues Asn91 …
Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase
SH Mohd-Pahmi, WM Hussein, G Schenk… - Bioorganic & medicinal …, 2011 - Elsevier
Purple acid phosphatases (PAPs) are binuclear metallohydrolases that have been isolated
from various mammals, plants, fungi and bacteria. In mammals PAP activity is associated …
from various mammals, plants, fungi and bacteria. In mammals PAP activity is associated …
Mechanistic role of each metal ion in Streptomyces dinuclear aminopeptidase: Peptide hydrolysis and 7× 1010-fold rate enhancement of phosphodiester hydrolysis
A Ercan, WM Tay, SH Grossman, LJ Ming - Journal of inorganic …, 2010 - Elsevier
The dinuclear aminopeptidase from Streptomyces griseus (SgAP) and its metal derivatives
catalyze the hydrolysis of the phosphoester bis (p-nitrophenyl) phosphate (BNPP) and the …
catalyze the hydrolysis of the phosphoester bis (p-nitrophenyl) phosphate (BNPP) and the …