The interactions of cells with extracellular matrices is of fundamental importance in many
biological processes such as embryological development, would healing and the …

The deadly feature of cancer, metastasis, requires invasion of cells through basement
membranes (BM), which normally act as barriers between tissue compartments. In the case …

Cell-extracellular matrix interactions have important roles in many biological processes,
including embryonic development, growth control and differentiation. Integrins are the …

Extracellular matrix proteins and their cellular receptors, integrins, play a fundamental role in
keratinocyte adhesion and migration. During wound healing, keratinocytes detach, migrate …

Laminin 5 regulates anchorage and motility of epithelial cells through integrins α6β4 and
α3β1, respectively. We used targeted disruption of the LAMA3 gene, which encodes the α3 …

The laminin-5 component of the extracellular matrices of certain cultured cells such as the
rat epithelial cell line 804G and the human breast epithelial cell MCF-10A is capable of …

Epiligrin, the major component of human keratinocyte extracellular matrix, serves as the
preferred integrin ligand for alpha 3 beta 1 in plasma membranes and focal adhesions, and …

Kalinin, a recently characterized novel protein component of anchoring filaments, has been
shown to be involved in keratinocyte attachment to culture substrates and to dermis in vivo …

Previously, we demonstrated that proteolytic processing within the globular domain of the α3
subunit of laminin-5 (LN5) converts LN5 from a cell motility-inducing factor to a protein …

We have linked Herlitz's junctional epidermolysis bullosa (H–JEB) to the gene (LAMC2)
encoding the γ2 subunit of nicein/kalinin, an isolaminin (laminin–5) expressed by basal …