Over 600 million years ago, animals evolved from a unicellular or colonial organism whose
cell (s) captured bacteria with a collar complex, a flagellum surrounded by a microvillar …

The borders between cell and developmental biology, which have always been permeable,
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …

During tumor progression, cancer cells come into contact with various non-tumor cell types,
but it is unclear how tumors adapt to these new environments. Here, we integrate spatially …

A hallmark of metazoan evolution is the emergence of genomic mechanisms that implement
cell-type-specific functions. However, the evolution of metazoan cell types and their …

Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …

Cilia are microtubule-based projections that serve a wide variety of essential functions in
animal cells. Defects in cilia structure or function have recently been found to underlie …

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is
characterized by dysfunction of insulin-producing pancreatic islet β cells1, 2. T2D genome …

Abstract Background The Amoebozoa constitute one of the primary divisions of eukaryotes,
encompassing taxa of both biomedical and evolutionary importance, yet its genomic …

The primary cilium is a ubiquitous microtubule-based organelle that senses external
environment and modulates diverse signaling pathways in different cell types and tissues …

1. A host for viruses 2. A host for yeast 3. A host for protists 4. Acanthamoeba and bacteria
interactions 5. Is Acanthamoebaan evolutionary ancestor of macrophages? 6 …