Epstein–Barr virus and multiple sclerosis

SS Soldan, PM Lieberman - Nature Reviews Microbiology, 2023 - nature.com
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting

M Charabati, MA Wheeler, HL Weiner, FJ Quintana - Cell, 2023 - cell.com
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations

W Barrie, Y Yang, EK Irving-Pease, KE Attfield… - Nature, 2024 - nature.com
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most
prevalent in Northern Europe. Although it is known that inherited risk for MS is located within …

How does the immune system enter the brain?

JA Mapunda, H Tibar, W Regragui… - Frontiers in …, 2022 - frontiersin.org
Multiple Sclerosis (MS) is considered the most frequent inflammatory demyelinating disease
of the central nervous system (CNS). It occurs with a variable prevalence across the world. A …

Applications of deep learning techniques for automated multiple sclerosis detection using magnetic resonance imaging: A review

A Shoeibi, M Khodatars, M Jafari, P Moridian… - Computers in Biology …, 2021 - Elsevier
Multiple Sclerosis (MS) is a type of brain disease which causes visual, sensory, and motor
problems for people with a detrimental effect on the functioning of the nervous system. In …

Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity

TL Montgomery, K Eckstrom, KH Lile, S Caldwell… - Microbiome, 2022 - Springer
Background Dysregulation of gut microbiota-associated tryptophan metabolism has been
observed in patients with multiple sclerosis. However, defining direct mechanistic links …

Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression

E Van San, AC Debruyne, G Veeckmans… - Cell Death & …, 2023 - nature.com
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by central nervous
(CNS) demyelination resulting in axonal injury and neurological deficits. Essentially, MS is …

Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics

E Kamma, W Lasisi, C Libner, HS Ng… - Journal of …, 2022 - Springer
There are over 15 disease-modifying drugs that have been approved over the last 20 years
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …

Thinking outside the box: non-canonical targets in multiple sclerosis

L Bierhansl, HP Hartung, O Aktas, T Ruck… - Nature reviews Drug …, 2022 - nature.com
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

Locus for severity implicates CNS resilience in progression of multiple sclerosis

MultipleMS Consortium Harroud Adil 1 78 78 Jónsdóttir … - Nature, 2023 - nature.com
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that
results in significant neurodegeneration in the majority of those affected and is a common …