Proximity-inducing modalities: the past, present, and future
Living systems use proximity to regulate biochemical processes. Inspired by this
phenomenon, bifunctional modalities that induce proximity have been developed to redirect …
phenomenon, bifunctional modalities that induce proximity have been developed to redirect …
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
GM Van Dam, G Themelis, LMA Crane, NJ Harlaar… - Nature medicine, 2011 - nature.com
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific
intraoperative fluorescence imaging may improve staging and debulking efforts in …
intraoperative fluorescence imaging may improve staging and debulking efforts in …
Prospects in folate receptor-targeted radionuclide therapy
Targeted radionuclide therapy is based on systemic application of particle-emitting
radiopharmaceuticals which are directed toward a specific tumor-associated target …
radiopharmaceuticals which are directed toward a specific tumor-associated target …
Redirection of genetically engineered CAR-T cells using bifunctional small molecules
Chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) provide a potent antitumor
response and have become a promising treatment option for cancer. However, despite their …
response and have become a promising treatment option for cancer. However, despite their …
Peptidic chimeric antigen receptor T cell switches and uses thereof
C07K I4/00(2006.01) US Appl. No. 14/432,065, Travis Young. C07K 6/00(2006.01) AXup, J.
et al., Synthesis of site-specific antibody-drug conjugates A6 IK 39/00(2006.01) using …
et al., Synthesis of site-specific antibody-drug conjugates A6 IK 39/00(2006.01) using …
Exploring binding and effector functions of natural human antibodies using synthetic immunomodulators
CE Jakobsche, CG Parker, RN Tao… - ACS chemical …, 2013 - ACS Publications
The ability to profile the prevalence and functional activity of endogenous antibodies is of
vast clinical and diagnostic importance. Serum antibodies are an important class of …
vast clinical and diagnostic importance. Serum antibodies are an important class of …
Folate based radiopharmaceuticals for imaging and therapy of cancer and inflammation
C Muller - Current pharmaceutical design, 2012 - ingentaconnect.com
Frequent overexpression of the folate receptor (FR) on a variety of tumor types and on
activated macrophages makes this re-ceptor an interesting target for both imaging and …
activated macrophages makes this re-ceptor an interesting target for both imaging and …
“Click and go”: simple and fast folic acid conjugation
AF Trindade, RFM Frade, EMS Maçôas… - Organic & …, 2014 - pubs.rsc.org
Folic acid targeting by functionalization of the terminal γ-carboxylic acid is one of the most
important strategies to selectively deliver chemotherapeutics and dyes to cancer cells which …
important strategies to selectively deliver chemotherapeutics and dyes to cancer cells which …
Photoswitchable CAR-T cell function in vitro and in vivo via a cleavable mediator
Chimeric antigen receptor (CAR)-T-based therapeutics are a breakthrough in cancer
treatment; however, they are hampered by constitutive activation, which leads to worrisome …
treatment; however, they are hampered by constitutive activation, which leads to worrisome …
A phase I study of folate immune therapy (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17) in patients with renal cell carcinoma
RJ Amato, A Shetty, Y Lu, R Ellis… - Journal of …, 2013 - journals.lww.com
This is the first phase I, open-label study to assess the safety, pharmacokinetics, and
antitumor activity of a novel immunotherapeutic regimen known as Folate Immune (EC90 …
antitumor activity of a novel immunotherapeutic regimen known as Folate Immune (EC90 …