The protective role of l-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats

HTAE Abd Elkader, MM Hussein… - Naunyn-Schmiedeberg's …, 2024 - Springer
Synthetic organic insecticides such as pyrethroids, organophosphates, neonicotinoids, and
others have the potential to disrupt ecosystems and are often toxic to humans …

Selenium alleviates modafinil-induced neurobehavioral toxicity in rat via PI3K/Akt/mTOR/GSK3B signaling pathway and suppression of oxidative stress and apoptosis …

SA Shehata, E Kolieb, DA Ali, SA Maher… - … Science and Pollution …, 2024 - Springer
Nonmedical use of modafinil (MOD) led to increased rates of overdose toxicity, road
accidents, addiction, withdrawal, suicide, and mental illnesses. The current study aims to …

Bioactivity Profiling of Chemical Mixtures for Hazard Characterization

X Li, J Zhou, Y Bai, M Qiao, W Xiong… - Environmental …, 2024 - ACS Publications
The assessment and regulation of chemical toxicity to protect human health and the
environment are done one chemical at a time and seldom at environmentally relevant …

L‐arginine mitigates choroid plexus changes in Alzheimer's disease rat model via oxidative/inflammatory burden and behavioral modulation

WAN El-Din, IOA Fattah - Tissue and Cell, 2024 - Elsevier
Aging is a risk factor for Alzheimer's disease (AD), leading to choroid plexus (CP) alterations.
This study aimed to explore the possible therapeutic mechanisms of ARG on AD-induced …

Betanin ameliorates fipronil-induced nephrotoxicity via activation of Nrf2-HO-1/NQO-1 pathway in albino rat model

S Sakr, A Hamed, M Atef - Toxicology Research, 2022 - academic.oup.com
Fipronil (FPN) is phenylpyrazole insecticide extensively used to control a wide variety of
pests. Betanin (BET) is a natural colorant with promising antioxidant and anti-inflammatory …

Molecular dynamics simulation studies on uptake of fipronil sulfone by gut microbiome and its influence on risk for cause of Parkinson's disease

A Bhat, V Chandramohan, S Sabat - Molecular Simulation, 2024 - Taylor & Francis
Biotransformation of Fipronil forms three metabolites: fipronil sulfone, fipronil sulfide and
fipronil desulfinyl. Among the triad of metabolites, fipronil sulfone exhibits quantitatively …

Histopathological and Behavioral Impairments in Zebrafish (Danio rerio) Chronically Exposed to a Cocktail of Fipronil and Pyriproxyfen

MA Robea, A Petrovici, D Ureche, M Nicoara… - Life, 2023 - mdpi.com
Background: Lately, the high incidence of pesticide usage has attracted everyone's interest
due to the serious effects produced. Fipronil (FIP) is a phenylpyrazole compound that acts …

Glucocorticoid hormones in relation to environmental exposure to bisphenols and multiclass pesticides among middle aged-women: Results from hair analysis

FJ Peng, P Palazzi, S Mezzache, E Adelin… - Environmental …, 2024 - Elsevier
Bisphenols and pesticides have been shown to alter circulating glucocorticoids levels in
animals, but there is limited human data. Moreover, measurements from biological fluids …

Neuromodulatory role of L-arginine: Nitric oxide precursor against thioacetamide-induced-hepatic encephalopathy in rats via downregulation of NF-κB-mediated …

AA Sedik, A Hassan, DO Saleh - Environmental Science and Pollution …, 2023 - Springer
The aim of the present study was to investigate the impact of arginine (ARG), a nitric oxide
(NO) precursor, on thioacetamide (TAA)-induced hepatic encephalopathy (HE) in rats by …

Induction of thymus atrophy and disruption of thymocyte development by fipronil through dysregulation of IL-7-associated genes

JF Kuo, HY Wu, CW Tung, WH Huang… - Chemical Research …, 2024 - ACS Publications
The susceptibility of the immune system to immunotoxic chemicals is evident, particularly in
the thymus, a vital primary immune organ prone to atrophy due to exposure to toxicants …