Streptomyces is taken as an important resource for producing the most abundant antibiotics
and other bio-active natural products, which have been widely used in pharmaceutical and …

Soil dwelling Streptomyces species are faced with large variations in carbon or nitrogen
sources, phosphate, oxygen, iron, sulfur, and other nutrients. These drastic changes in key …

Streptomyces antibiotic regulatory protein (SARP) family regulators are well-known
activators of antibiotic biosynthesis in streptomycetes. The respective genes occur in various …

Genome mining of one of the protective symbionts (Burkholderia gladioli) of the invasive
beetle Lagria villosa revealed a cryptic gene cluster that codes for the biosynthesis of a …

Highlights•γ-Butyrolactone (GBL) hormones regulate antibiotic production in many
Streptomyces species.•GBL-based systems could be used to design orthogonal switches in …

In model organism Streptomyces coelicolor, γ-butyrolactones (GBLs) and antibiotics were
recognized as signalling molecules playing fundamental roles in intra-and interspecies …

Pristinamycin production in Streptomyces pristinaespiralis Pr11 is tightly regulated by an
interplay between different repressors and activators. A γ-butyrolactone receptor gene …

The analysis of the inorganic phosphate effect over the antibiotics production is a long-
distance history in the Streptomyces genus, which began almost at the same time that …

The emergence of antibiotic-resistant pathogen microorganisms is problematic in the context
of the current spectrum of available medication. The poor specificity and the high toxicity of …

Abstract Tacrolimus (FK506), an effective immunosuppressant, is widely used in the
treatment of autoimmune diseases. In this study, we identified that BulZ, a Streptomyces …