webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study
The development of transcriptome-wide association studies (TWAS) has enabled
researchers to better identify and interpret causal genes in many diseases. However, there …
researchers to better identify and interpret causal genes in many diseases. However, there …
A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits
The development of polygenic risk scores (PRSs) has proved useful to stratify the general
European population into different risk groups. However, PRSs are less accurate in non …
European population into different risk groups. However, PRSs are less accurate in non …
Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics
Mendelian randomization (MR) is a valuable tool for inferring causal relationships among a
wide range of traits using summary statistics from genome-wide association studies …
wide range of traits using summary statistics from genome-wide association studies …
Causal inference in transcriptome-wide association studies with invalid instruments and GWAS summary data
Abstract Transcriptome-Wide Association Studies (TWAS) have recently emerged as a
popular tool to discover (putative) causal genes by integrating an outcome GWAS dataset …
popular tool to discover (putative) causal genes by integrating an outcome GWAS dataset …
A review of statistical methods for identifying trait-relevant tissues and cell types
Genome-wide association studies (GWASs) have identified and replicated many genetic
variants that are associated with diseases and disease-related complex traits. However, the …
variants that are associated with diseases and disease-related complex traits. However, the …
Inferring causal direction between two traits in the presence of horizontal pleiotropy with GWAS summary data
Orienting the causal relationship between pairs of traits is a fundamental task in scientific
research with significant implications in practice, such as in prioritizing molecular targets and …
research with significant implications in practice, such as in prioritizing molecular targets and …
Transcriptome profiling at osmotic and ionic phases of salt stress response in bread wheat uncovers trait-specific candidate genes
Background Bread wheat is one of the most important crops for the human diet, but the
increasing soil salinization is causing yield reductions worldwide. Improving salt stress …
increasing soil salinization is causing yield reductions worldwide. Improving salt stress …
A robust two‐sample transcriptome‐wide Mendelian randomization method integrating GWAS with multi‐tissue eQTL summary statistics
KJ Gleason, F Yang, LS Chen - Genetic epidemiology, 2021 - Wiley Online Library
By treating genetic variants as instrumental variables (IVs), two‐sample Mendelian
randomization (MR) methods detect genetically regulated risk exposures for complex …
randomization (MR) methods detect genetically regulated risk exposures for complex …
Leveraging the local genetic structure for trans-ancestry association mapping
Over the past two decades, genome-wide association studies (GWASs) have successfully
advanced our understanding of the genetic basis of complex traits. Despite the fruitful …
advanced our understanding of the genetic basis of complex traits. Despite the fruitful …
A tissue-specific collaborative mixed model for jointly analyzing multiple tissues in transcriptome-wide association studies
Transcriptome-wide association studies (TWASs) integrate expression quantitative trait loci
(eQTLs) studies with genome-wide association studies (GWASs) to prioritize candidate …
(eQTLs) studies with genome-wide association studies (GWASs) to prioritize candidate …