Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate
janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling …

The progression of cancer involves not only the gradual evolution of cells by mutations in
DNA but also alterations in the gene expression induced by those mutations and input from …

Tumor immunotherapy based on immune checkpoint blockade (ICB) still suffers from low
host response rate and non‐specific distribution of immune checkpoint inhibitors, greatly …

In the current study, we have shown that USP51 promotes colorectal cancer stemness and
chemoresistance, and high expression of USP51 predicts survival disadvantage in …

Purpose Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely
studied for more than six decades. Here we review the importance of hypoxia to …

Background Breast cancer is the most common cancer worldwide. Hypoxia and lactate
metabolism are hallmarks of cancer. This study aimed to construct a novel hypoxia-and …

The most recent genome-wide association study (GWAS) of cutaneous melanoma identified
54 risk-associated loci, but functional variants and their target genes for most have not been …

While the extracellular matrix (ECM) has long been recognized for its structural
contributions, anchoring cells for adhesion, providing mechanical support, and maintaining …

Non-coding RNA has aroused great research interest recently, they play a wide range of
biological functions, such as regulating cell cycle, cell proliferation, and intracellular …

The categorization of cancers demonstrates that prostate cancer is the most common
malignancy in men and it causes high death annually. Prostate cancer patients are …