Neurodegenerative diseases exert an overwhelming socioeconomic burden all around the
globe. They are mainly characterized by modified protein accumulation that might trigger …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), is challenging to model in
mice. Not only is it a contiguous gene syndrome spanning 35 Mb of the long arm of Hsa21 …

Down syndrome (DS) is a genetic disorder caused by the presence of a third copy of
chromosome 21. DS affects multiple organs, but it invariably results in altered brain …

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this …

Down syndrome (DS) is a genetic disease that occurs due to an aneuploidy of human
chromosome 21. Trisomy of chromosome 21 is a primary genetic cause of developmental …

Down syndrome (DS) caused by a trisomy of chromosome 21 (HSA21), is the most common
genetic developmental disorder, with an incidence of 1 in 800 live births. Its phenotypic …

Polyphenols are secondary metabolites of plants largely found in fruits, vegetables, cereals
and beverages, and therefore represent important constituents of the human diet. Increasing …

In recent years, neurological and neurodegenerative disorders research has focused on
altered molecular mechanisms in search of potential pharmacological targets, eg …

Background Theanine, an amino acid in tea, has significant anti-stress effects on animals
and humans. However, the anti-stress effects of drinking green tea have not yet been …