The transition of AKI to CKD has major clinical significance. As reviewed here, recent studies
show that a subpopulation of dedifferentiated, proliferating tubules recovering from AKI …

In the United States the prevalence of end-stage renal disease (ESRD) reached epidemic
proportions in 2012 with over 600,000 patients being treated. The rates of ESRD among the …

During recovery by regeneration after AKI, proximal tubule cells can fail to redifferentiate,
undergo premature growth arrest, and become atrophic. The atrophic tubules display …

Acute kidney injury (AKI) is a multifactorial entity that occurs in a variety of clinical settings.
Although AKI is not a usual reason for intensive care unit (ICU) admission, it often …

Tissue hypoxia has been proposed as an important factor in the pathophysiology of both
chronic kidney disease (CKD) and acute kidney injury (AKI), initiating and propagating a …

After shock, persistent oxygen extraction deficit despite the apparent adequate recovery of
systemic hemodynamic and oxygen-derived variables has been a source of uncertainty and …

Background Acute kidney injury (AKI) is common after cardiac surgery and profoundly
affects postoperative mortality and morbidity. There are no validated methods to assess risk …

Renal tissue hypoperfusion and hypoxia are key elements in the pathophysiology of acute
kidney injury and its progression to chronic kidney disease. Yet, in vivo assessment of renal …

Extracorporeal membrane oxygenation (ECMO) is a modified cardiopulmonary bypass
(CPB) circuit capable of providing prolonged cardiorespiratory support. Recent …

Diabetic nephropathy (DN) is now a leading cause of end‐stage renal disease. In addition,
DN accounts for the increased mortality in type 1 and type 2 diabetes, and then patients …