Hyperpolarization-activated cation channels: from genes to function
M Biel, C Wahl-Schott, S Michalakis… - Physiological …, 2009 - journals.physiology.org
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …
Neurophysiology of HCN channels: from cellular functions to multiple regulations
C He, F Chen, B Li, Z Hu - Progress in neurobiology, 2014 - Elsevier
Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …
involved in multiple physiological processes.•HCN channels are excellent targets of various …
HCN channels: function and clinical implications
EE Benarroch - Neurology, 2013 - AAN Enterprises
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels belong to the
superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises 4 …
superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises 4 …
Exploring HCN channels as novel drug targets
O Postea, M Biel - Nature reviews Drug discovery, 2011 - nature.com
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on …
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on …
Research advances in basic mechanisms of seizures and antiepileptic drug action
W Lasoń, M Chlebicka, K Rejdak - Pharmacological Reports, 2013 - Elsevier
Epilepsy is a common neurological disease but the mechanism of seizure generation has
been only partially unraveled. Furthermore, almost 30% of epileptic patients are resistant to …
been only partially unraveled. Furthermore, almost 30% of epileptic patients are resistant to …
Febrile seizures: mechanisms and relationship to epilepsy
Studies of febrile seizures have been driven by two major enigmas: first, how these most
common of human seizures are generated by fever has not been known. Second …
common of human seizures are generated by fever has not been known. Second …
Dysfunctional HCN ion channels in neurological diseases
JC DiFrancesco, D DiFrancesco - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
Neuron‐restrictive silencer factor‐mediated hyperpolarization‐activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy
S McClelland, C Flynn, C Dubé, C Richichi… - Annals of …, 2011 - Wiley Online Library
Objective: Enduring, abnormal expression and function of the ion channel hyperpolarization‐
activated cyclic adenosine monophosphate gated channel type 1 (HCN1) occurs in temporal …
activated cyclic adenosine monophosphate gated channel type 1 (HCN1) occurs in temporal …
Fetuin-A: the missing link in lipid-induced inflammation
J Heinrichsdorff, JM Olefsky - Nature medicine, 2012 - nature.com
The liver secretory protein fetuin-A (FetA) is now shown to act as an adaptor protein between
free fatty acids (FFAs) and Toll-like receptor 4 (TLR4), providing the missing link between …
free fatty acids (FFAs) and Toll-like receptor 4 (TLR4), providing the missing link between …
The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes
The mechanisms generating epileptic neuronal networks following insults such as severe
seizures are unknown. We have previously shown that interfering with the function of the …
seizures are unknown. We have previously shown that interfering with the function of the …