Eighty-three brains obtained at autopsy from nondemented and demented individuals were
examined for extracellular amyloid deposits and intraneuronal neurofibrillary changes. The …

The idea of reserve against brain damage stems from the repeated observation that there
does not appear to be a direct relationship between the degree of brain pathology or brain …

We studied the accumulation of neurofibrillary tangles (NFTs) and senile plaques (SPs) in
10 Alzheimer's disease patients who had been examined during life. We counted NFTs and …

Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by
cognitive and intellectual deficits and behavior disturbance. The electroencephalogram …

The distribution of neurofibrillary tangles (NFTs) and neuritic plaques (NPs) was mapped in
39 cortical areas of 11 brains of patients with Alzheimer's disease (AD). Whole hemisphere …

Objective: To examine the relationship between stereologic estimates of AD-related
pathology and severity of cognitive deficits in brain aging. Background: Previous studies …

Neurodegenerative disorders are characterized by extensive neuron death that leads to
functional decline, but the neurobiological correlates of functional decline in normal aging …

HLA-DR is a class II major histocompatibility complex antigen which in the periphery confers
antigen presenting capability. We have previously shown that this marker is profusely …

Abstract The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying
the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain …

Neurofibrillary tangles and senile plaques, together with cells immunoreactive for the Alz-50
antibody (A50-ir cells) or for an antibody against paired helical filaments (PHF-ir cells), and …