How to conduct and interpret ITC experiments accurately for cyclodextrin–guest interactions

K Bouchemal, S Mazzaferro - Drug Discovery Today, 2012 - Elsevier
Isothermal titration calorimetry (ITC) is one of the most interesting methods for the
characterization of the interaction mechanisms of cyclodextrins (CDs) with drugs. In this …

Polypeptide‐Based Conjugates as Therapeutics: Opportunities and Challenges

O Zagorodko, JJ Arroyo‐Crespo… - Macromolecular …, 2017 - Wiley Online Library
Synthetic polypeptides or polyamino acids have become a useful and multifunctional
platform in advanced drug delivery studies. Nonetheless, the full potential of these systems …

Precipitation of nanohydroxyapatite on PLLA/PBLG/Collagen nanofibrous structures for the differentiation of adipose derived stem cells to osteogenic lineage

R Ravichandran, JR Venugopal, S Sundarrajan… - Biomaterials, 2012 - Elsevier
Tissue engineering and nanotechnology have enabled engineering of nanostructured
materials to meet the current challenges in bone treatment owing to rising occurrence of …

[HTML][HTML] Improving aqueous solubility of paclitaxel with polysarcosine-b-poly (γ-benzyl glutamate) nanoparticles

C Lebleu, L Plet, F Moussy, G Gitton… - International Journal of …, 2023 - Elsevier
New stealth amphiphilic copolymers based on polysarcosine (PSar) rather than poly
(ethylene glycol)(PEG) have gained more attention for their use as excipients in …

Biomimetic composites and stem cells interaction for bone and cartilage tissue regeneration

N Naveena, J Venugopal, R Rajeswari… - Journal of Materials …, 2012 - pubs.rsc.org
Development of bone and cartilage are emerging as prominent techniques in the field of
tissue engineering because of the abundance of problems caused by disease, injury and …

Poly (γ-benzyl-l-glutamate)-PEG-alendronate multivalent nanoparticles for bone targeting

L de Miguel, M Noiray, G Surpateanu, BI Iorga… - International journal of …, 2014 - Elsevier
Hydroxyapatite (HAP), a highly specific component of bone tissue, is the main target in order
to impart osteotropicity. Bone targeted nanoparticles can increase the strength of the …

Glycyrrhetinic acid-functionalized degradable micelles as liver-targeted drug carrier

W Huang, W Wang, P Wang, CN Zhang, Q Tian… - Journal of Materials …, 2011 - Springer
Recently, many efforts have been devoted to investigating the application of functionalized
micelles as targeted drug delivery carriers. In this study, glycyrrhetinic acid (GA, a liver …

Pegylation of poly (γ-benzyl-L-glutamate) nanoparticles is efficient for avoiding mononuclear phagocyte system capture in rats

I Özcan, F Segura-Sánchez, K Bouchemal… - International journal …, 2010 - Taylor & Francis
Poly (γ-benzyl-L-glutamate)(PBLG) derivatives are synthetic polypeptides for preparing
nanoparticles with well controlled surface properties. The aim of this paper was to …

Polymeric micelles based on poly (ethylene glycol) block poly (racemic amino acids) hybrid polypeptides: conformation-facilitated drug-loading behavior and potential …

PF Gu, H Xu, BW Sui, JX Gou, LK Meng… - International journal …, 2012 - Taylor & Francis
In this work, racemic hybrid polypeptides poly (ethylene glycol)(PEG)-b-poly (racemic-
leucine)(PRL) copolymers with different leucine residues have been synthesized and …

Amphiphilic PEO‐b‐PBLG Diblock and PBLG‐b‐PEO‐b‐PBLG Triblock Copolymer Based Nanoparticles: Doxorubicin Loading and In Vitro Evaluation

D Kakkar, S Mazzaferro, J Thevenot… - Macromolecular …, 2015 - Wiley Online Library
Huisgen's 1, 3‐dipolar cycloaddition (“Click Chemestry”) has been used to prepare
amphiphilic PEO‐b‐PBLG diblock and PBLG‐b‐PEO‐b‐PBLG triblock copolymers as …