The macrolide antibiotic renaissance

GP Dinos - British journal of pharmacology, 2017 - Wiley Online Library
Macrolides represent a large family of protein synthesis inhibitors of great clinical interest
due to their applicability to human medicine. Macrolides are composed of a macrocyclic …

Quantitative NMR spectroscopy—applications in drug analysis

U Holzgrabe, R Deubner, C Schollmayer… - … of pharmaceutical and …, 2005 - Elsevier
NMR spectroscopy being a primary ratio method of measurement is highly suitable to
evaluate the quality of drugs. NMR spectroscopy can be used for the identification of a drug …

Removal of antibiotics, antibiotic-resistant bacteria and their associated genes by graphene-based TiO2 composite photocatalysts under solar radiation in urban …

P Karaolia, I Michael-Kordatou, E Hapeshi… - Applied Catalysis B …, 2018 - Elsevier
The present work investigated:(i) the removal of the antibiotics sulfamethoxazole (SMX),
erythromycin (ERY) and clarithromycin (CLA);(ii) the inactivation of the total and antibiotic …

Translation and protein synthesis: macrolides

L Katz, GW Ashley - Chemical reviews, 2005 - ACS Publications
The term “macrolide” was originally proposed by RB Woodward in 1957 as an abbreviation
of macrolactone glycoside antibiotics, a class of natural products composed of macrocyclic …

Biodegradation efficiency and mechanism of erythromycin degradation by Paracoccus versutus W7

J Ren, X Qi, J Zhang, D Niu, Y Shen, C Yu, J Zhi… - Journal of …, 2023 - Elsevier
Continuous and excessive usage of erythromycin results in serious environmental pollution
and presents a health risk to humans. Biological treatment is considered as an efficient and …

Implications of designing clarithromycin loaded solid lipid nanoparticles on their pharmacokinetics, antibacterial activity and safety

M Sharma, N Gupta, S Gupta - RSC advances, 2016 - pubs.rsc.org
The major obstacles for treatment of intracellular infections with clarithromycin are poor
gastrointestinal solubility, short half-life (3–4 h), low oral bioavailability and hepatotoxicity …

On the photodegradation of azithromycin, erythromycin and tylosin and their transformation products–A kinetic study

M Voigt, M Jaeger - Sustainable Chemistry and Pharmacy, 2017 - Elsevier
In this study, the photo-induced degradation of azithromycin (Azi), erythromycin (Ery) and
tylosin (Tyl) was investigated. The three macrolides are regularly found in different kinds of …

True chemical shift correlation maps: a TOCSY experiment with pure shifts in both dimensions

GA Morris, JA Aguilar, R Evans, S Haiber… - Journal of the …, 2010 - ACS Publications
Signal resolution in 1H NMR is limited primarily by multiplet structure. Recent advances in
pure shift NMR, in which the effects of homonuclear couplings are suppressed, have …

Combatting Helicobacter pylori with oral nanomedicines

Y Qin, YH Lao, H Wang, J Zhang, K Yi… - Journal of Materials …, 2021 - pubs.rsc.org
Helicobacter pylori (H. pylori) infection is considered to be the main cause of most digestive
diseases, such as chronic active gastritis, gastroduodenal ulcers, or even gastric cancer …

Adsorption and transformation of selected human-used macrolide antibacterial agents with iron (III) and manganese (IV) oxides

J Feitosa-Felizzola, K Hanna, S Chiron - Environmental Pollution, 2009 - Elsevier
The adsorption/transformation of two members (clarithromycin and roxithromycin) of the
macrolide (ML) antibacterial agents on the surface of three environmental subsurface …